دورية أكاديمية
Blocking FSH induces thermogenic adipose tissue and reduces body fat.
| العنوان: | Blocking FSH induces thermogenic adipose tissue and reduces body fat. |
|---|---|
| المؤلفون: | Liu, Peng, Ji, Yaoting, Yuen, Tony, Rendina-Ruedy, Elizabeth, DeMambro, Victoria E, Dhawan, Samarth, Abu-Amer, Wahid, Izadmehr, Sudeh, Zhou, Bin, Shin, Andrew C, Latif, Rauf, Thangeswaran, Priyanthan, Gupta, Animesh, Li, Jianhua, Shnayder, Valeria, Robinson, Samuel T, Yu, Yue Eric, Zhang, Xingjian, Yang, Feiran, Lu, Ping, Zhou, Yu, Zhu, Ling-Ling, Oberlin, Douglas J, Davies, Terry F, Reagan, Michaela R, Brown, Aaron, Kumar, T Rajendra, Epstein, Solomon, Iqbal, Jameel, Avadhani, Narayan G, New, Maria I, Molina, Henrik, van Klinken, Jan B, Guo, Edward X, Buettner, Christoph, Haider, Shozeb, Bian, Zhuan, Sun, Li, Rosen, Clifford J, Zaidi, Mone |
| المصدر: | Maine Medical Center |
| بيانات النشر: | MaineHealth Knowledge Connection |
| سنة النشر: | 2017 |
| المجموعة: | MaineHealth Knowledge Connection |
| مصطلحات موضوعية: | Adipocytes, Adipose Tissue, Beige, White, Adiposity, Animals, Antibodies, Diet, High-Fat, Female, Follicle Stimulating Hormone, beta Subunit, Haploinsufficiency, Male, Mice, Mitochondria, Obesity, Osteoporosis, Ovariectomy, Oxygen Consumption, Receptors, FSH, Thermogenesis, Uncoupling Protein 1, Endocrine System, Endocrinology, Diabetes, and Metabolism, Medical Cell Biology, Obstetrics and Gynecology |
| الوصف: | Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://knowledgeconnection.mainehealth.org/mmc/579Test; https://www.ncbi.nlm.nih.gov/pubmed/28538730Test/ |
| الإتاحة: | https://knowledgeconnection.mainehealth.org/mmc/579Test https://www.ncbi.nlm.nih.gov/pubmed/28538730Test/ |
| رقم الانضمام: | edsbas.BCD3BF5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |