دورية أكاديمية
Practical implementation and clinical benefits of the new automated dialysate sodium control biosensor
| العنوان: | Practical implementation and clinical benefits of the new automated dialysate sodium control biosensor |
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| المؤلفون: | Maduell, Francisco, Broseta, José J, Rodríguez-Espinosa, Diana, Casals, Joaquim, Escudero, Victor, Gomez, Miquel, Rodas, Lida M, Arias-Guillén, Marta, Vera, Manel, Fontseré, Néstor |
| المصدر: | Clinical Kidney Journal ; volume 16, issue 5, page 859-867 ; ISSN 2048-8505 2048-8513 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Background A key feature of dialysis treatment is the prescription of dialysate sodium (Na). This study aimed to describe the practical implementation of a new automated dialysate Na control biosensor and to assess its tolerance and the beneficial clinical effects of isonatraemic dialysis. Methods A prospective study was carried out in 86 patients who, along with their usual parameters, received the following five consecutive phases of treatment for 3 weeks each: phase 0: baseline 5008 machine; phases 1 and 2: 6008 machine without activation of the Na control biosensor and the same fixed individualized Na dialysate prescription or adjusted to obtain similar conductivity to phase 0; phases 3 and 4: activated Na control to isonatraemic dialysis (Na dialysate margins 135–141 or 134–142 mmol/L). Results When the Na control was activated, the few episodes of cramps or hypotension disappeared when the lower dialysate Na margin was increased by 1 or 2 mmol/L. The activated Na control module showed significant differences compared with baseline and the non-activated Na module in final serum Na values, diffusive Na balance, and changes in pre- to postdialysis plasma Na values. The mean predialysis systolic blood pressure value was significantly lower in phase 4 than in phase 1. There were no significant differences in total Na balance in the four 6008 phases evaluated. Conclusions The implementation of the automated dialysate Na control module is a useful new tool, which reduced the diffusive load of Na with good tolerance. The module had the advantages of reducing thirst, interdialytic weight gain and intradialytic plasma Na changes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ckj/sfad013 |
| DOI: | 10.1093/ckj/sfad013/49628561/sfad013.pdf |
| الإتاحة: | https://doi.org/10.1093/ckj/sfad013Test https://academic.oup.com/ckj/article-pdf/16/5/859/56811880/sfad013.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.BCCAC19E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ckj/sfad013 |
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