دورية أكاديمية
Role of PTP1B in HER2 Signaling in Breast Cancer
| العنوان: | Role of PTP1B in HER2 Signaling in Breast Cancer |
|---|---|
| المؤلفون: | Saha, Sayanti |
| المساهمون: | INSTITUTE FOR CANCER RESEARCH PHILADELPHIA PA |
| المصدر: | DTIC |
| سنة النشر: | 2012 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Medicine and Medical Research, BREAST CANCER, EPITHELIUM, RECEPTOR SITES(PHYSIOLOGY), CELLS(BIOLOGY), CLINICAL MEDICINE, CROSSTALK, CYTOPLASM, DRUGS, ENZYMES, IN VITRO ANALYSIS, IN VIVO ANALYSIS, MAMMARY GLANDS, ONCOGENESIS, PHOSPHATASES, PHOSPHORUS TRANSFERASES, PROTEINS, TARGETS, THERAPY, TRACER STUDIES, TYROSINE, SUBSTRATE TRAP, PHOSPHOPROTEOMICS |
| الوصف: | The receptor tyrosine kinase ErbB2 is overexpressed in approximately 25% of all breast cancers. ErbB2, and the signaling pathways it activates, represent potential selective targets for therapy in breast cancer. However, drug resistance is a significant clinical problem with current ErbB2-targeted breast cancer therapies. This is because of our lack of understanding of the molecular mechanism underlying the role of ErbB2 in breast carcinogenesis. Recently, Dr. Chernoff and others have reported that a cytoplasmic enzyme, protein tyrosine phosphatase 1B (PTP1B) plays a positive role in ErbB2-induced breast cancer in vitro and in vivo. Therefore, a detailed understanding of the signaling crosstalk between ErbB2 and PTP1B regulated pathways is warranted. In this research proposal, I have aimed to identify key pro-oncogenic PTP1B regulated pathways in ErbB2 signaling in MCF10A breast epithelial cells using quantitative phosphoproteomics. This study has the potential to uncover novel molecular targets in ErbB2- positive breast cancer and is expected to provide new hope and direction to the present breast cancer biomarkers and therapeutics. ; The original document contains color images. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://www.dtic.mil/docs/citations/ADA579832Test |
| الإتاحة: | http://www.dtic.mil/docs/citations/ADA579832Test http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA579832Test |
| حقوق: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.BC78D22D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |