دورية أكاديمية
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
| العنوان: | A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids |
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| المؤلفون: | Million Veterans Program, Global Lipids Genetics Consortium |
| المساهمون: | Clinical Laboratory Services, Diagnostics and Blood Bank, Faculty of Medicine, Engineering and Natural Sciences, Health Sciences |
| سنة النشر: | 2022 |
| المجموعة: | Opin vísindi (Iceland) |
| مصطلحات موضوعية: | Lífefna- og sameindalíffræði, complex traits, fine-mapping, functional genomics, lipid biology, post-GWAS, regulatory mechanism, variant prioritization, Genetics, Genetics (clinical) |
| الوصف: | Funding Information: Xiang Zhu is supported by the Stein Fellowship from Stanford University and Institute for Computational and Data Sciences Seed Grant from The Pennsylvania State University. C.D.B. is supported by the NIH (R01-HL133218). Funding for the Global Lipids Genetics Consortium was provided by the NIH (R01-HL127564). This research was conducted using the UK Biobank Resource under application number 24460. This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, and was supported by awards 2I01BX003362-03A1 and 1I01BX004821-01A1. This publication does not represent the views of the Department of Veteran Affairs or the United States Government. We thank Bethany Klunder for administrative support. Study-specific acknowledgments are provided in the supplemental information. G.C.-P. is currently an employee of 23andMe Inc. M.J.C. is the Chief Scientist for Genomics England, a UK Government company. B.M. Psaty serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. G. Thorleifsson, A.H. D.F.G. H. Holm, U.T. and K.S. are employees of deCODE/Amgen Inc. V.S. has received honoraria for consultations from Novo Nordisk and Sanofi and has an ongoing research collaboration with Bayer Ltd. M. McCarthy has served on advisory panels for Pfizer, NovoNordisk, and Zoe Global and has received honoraria from Merck, Pfizer, Novo Nordisk, and Eli Lilly and research funding from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier, and Takeda. M. McCarthy and A. Mahajan are employees of Genentech and holders of Roche stock. M.S. receives funding from Pfizer Inc. for a project unrelated to this work. M.E.K. is employed by SYNLAB MVZ Mannheim GmbH. W.M. has received grants from Siemens Healthineers, grants and personal fees from Aegerion Pharmaceuticals, grants and personal fees from AMGEN, grants from Astrazeneca, grants and personal ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1366-1387 |
| اللغة: | English |
| ردمك: | 978-85-13-55987-1 85-13-55987-3 |
| تدمد: | 0002-9297 |
| العلاقة: | American Journal of Human Genetics; 109(8); http://www.scopus.com/inward/record.url?scp=85135598739&partnerID=8YFLogxKTest; Million Veterans Program & Global Lipids Genetics Consortium 2022 , ' A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids ' , American Journal of Human Genetics , vol. 109 , no. 8 , pp. 1366-1387 . https://doi.org/10.1016/j.ajhg.2022.06.012Test; 075d0335-b9a4-4bc4-bdec-79edf5405a25; 85135598739; https://hdl.handle.net/20.500.11815/4084Test |
| DOI: | 10.1016/j.ajhg.2022.06.012 |
| الإتاحة: | https://doi.org/20.500.11815/4084Test https://doi.org/10.1016/j.ajhg.2022.06.012Test https://hdl.handle.net/20.500.11815/4084Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BC75BFBE |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9788513559871 8513559873 |
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| تدمد: | 00029297 |
| DOI: | 10.1016/j.ajhg.2022.06.012 |