دورية أكاديمية
Update on glycosphingolipids abundance in hepatocellular carcinoma
| العنوان: | Update on glycosphingolipids abundance in hepatocellular carcinoma |
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| المؤلفون: | Byrne, Frances L., Olzomer, Ellen M., Lolies, Nina, Hoehn, Kyle L., Wegner, Marthe-Susanna |
| سنة النشر: | 2022 |
| المجموعة: | Publication Server of Goethe University Frankfurt am Main |
| مصطلحات موضوعية: | ddc:540, ddc:570, ddc:610 |
| الوصف: | Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer. Low numbers of HCC patients being suitable for liver resection or transplantation and multidrug resistance development during pharmacotherapy leads to high death rates for HCC patients. Understanding the molecular mechanisms of HCC etiology may contribute to the development of novel therapeutic strategies for prevention and treatment of HCC. UDP-glucose ceramide glycosyltransferase (UGCG), a key enzyme in glycosphingolipid metabolism, generates glucosylceramide (GlcCer), which is the precursor for all glycosphingolipids (GSLs). Since UGCG gene expression is altered in 0.8% of HCC tumors, GSLs may play a role in cellular processes in liver cancer cells. Here, we discuss the current literature about GSLs and their abundance in normal liver cells, Gaucher disease and HCC. Furthermore, we review the involvement of UGCG/GlcCer in multidrug resistance development, globosides as a potential prognostic marker for HCC, gangliosides as a potential liver cancer stem cell marker, and the role of sulfatides in tumor metastasis. Only a limited number of molecular mechanisms executed by GSLs in HCC are known, which we summarize here briefly. Overall, the role GSLs play in HCC progression and their ability to serve as biomarkers or prognostic indicators for HCC, requires further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/80413Test; urn:nbn:de:hebis:30:3-804131; https://nbn-resolving.org/urn:nbn:de:hebis:30:3-804131Test; https://doi.org/10.3390/ijms23094477Test; http://publikationen.ub.uni-frankfurt.de/files/80413/ijms-23-04477.pdfTest |
| DOI: | 10.3390/ijms23094477 |
| الإتاحة: | https://doi.org/10.3390/ijms23094477Test http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/80413Test https://nbn-resolving.org/urn:nbn:de:hebis:30:3-804131Test http://publikationen.ub.uni-frankfurt.de/files/80413/ijms-23-04477.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0/deed.deTest ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BC656F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms23094477 |
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