دورية أكاديمية
Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum
| العنوان: | Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum |
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| المؤلفون: | Dore, V, Doecke, JD, Saad, ZS, Triana-Baltzer, G, Slemmon, R, Krishnadas, N, Bourgeat, P, Huang, K, Burnham, S, Fowler, C, Rainey-Smith, SR, Bush, AI, Ward, L, Robertson, J, Martins, RN, Masters, CL, Villemagne, VL, Fripp, J, Kolb, HC, Rowe, CC |
| بيانات النشر: | WILEY |
| سنة النشر: | 2022 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | INTRODUCTION: We evaluated a new Simoa plasma assay for phosphorylated tau (P-tau) at aa217 enhanced by additional p-tau sites (p217+tau). METHODS: Plasma p217+tau levels were compared to 18F-NAV4694 amyloid beta (Aβ) positron emission tomography (PET) and 18F-MK6240 tau PET in 174 cognitively impaired (CI) and 223 cognitively unimpaired (CU) participants. RESULTS: Compared to Aβ- CU, the plasma levels of p217+tau increased 2-fold in Aβ+ CU and 3.5-fold in Aβ+ CI. In Aβ- the p217+tau levels did not differ significantly between CU and CI. P217+tau correlated with Aβ centiloids P = .67 (CI, P = .64; CU, P = .45) and tau SUVRMT P = .63 (CI, P = .69; CU, P = .34). Area under curve (AUC) for Alzheimer's disease (AD) dementia versus Aβ- CU was 0.94, for AD dementia versus other dementia was 0.93, for Aβ+ versus Aβ- PET was 0.89, and for tau+ versus tau- PET was 0.89. DISCUSSION: Plasma p217+tau levels elevate early in the AD continuum and correlate well with Aβ and tau PET. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2352-8729 |
| العلاقة: | NHMRC/1152623; pii: DAD212307; Dore, V., Doecke, J. D., Saad, Z. S., Triana-Baltzer, G., Slemmon, R., Krishnadas, N., Bourgeat, P., Huang, K., Burnham, S., Fowler, C., Rainey-Smith, S. R., Bush, A. I., Ward, L., Robertson, J., Martins, R. N., Masters, C. L., Villemagne, V. L., Fripp, J., Kolb, H. C. & Rowe, C. C. (2022). Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 14 (1), https://doi.org/10.1002/dad2.12307Test.; http://hdl.handle.net/11343/307217Test |
| الإتاحة: | https://doi.org/10.1002/dad2.12307Test http://hdl.handle.net/11343/307217Test |
| حقوق: | CC BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0Test |
| رقم الانضمام: | edsbas.BC109CD9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23528729 |
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