دورية أكاديمية
Perivascular-Derived Mesenchymal Stem Cells
| العنوان: | Perivascular-Derived Mesenchymal Stem Cells |
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| المؤلفون: | Yianni, V., Sharpe, P.T. |
| المصدر: | Yianni , V & Sharpe , P T 2019 , ' Perivascular-Derived Mesenchymal Stem Cells ' , Journal of Dental Research , vol. 98 , no. 10 , 002203451986225 , pp. 1066-1072 . https://doi.org/10.1177/0022034519862258Test |
| سنة النشر: | 2019 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | epigenetics, mesenchymal stromal cell, pericytes, perivascular stem cell, regeneration, tissue repair |
| الوصف: | Cells have been identified in postnatal tissues that, when isolated from multiple mesenchymal compartments, can be stimulated in vitro to give rise to cells that resemble mature mesenchymal phenotypes, such as odontoblasts, osteoblasts, adipocytes, and myoblasts. This has made these adult cells, collectively called mesenchymal stem cells (MSCs), strong candidates for fields such as tissue engineering and regenerative medicine. Based on evidence from in vivo genetic lineage–tracing studies, pericytes have been identified as a source of MSC precursors in vivo in multiple organs, in response to injury or during homeostasis. Questions of intense debate and interest in the field of tissue engineering and regenerative studies include the following: 1) Are all pericytes, irrespective of tissue of isolation, equal in their differentiation potential? 2) What are the mechanisms that regulate the differentiation of MSCs? To gain a better understanding of the latter, recent work has utilized ChIP-seq (chromatin immunoprecipitation followed by sequencing) to reconstruct histone landscapes. This indicated that for dental pulp pericytes, the odontoblast-specific gene Dspp was found in a transcriptionally permissive state, while in bone marrow pericytes, the osteoblast-specific gene Runx2 was primed for expression. RNA sequencing has also been utilized to further characterize the 2 pericyte populations, and results highlighted that dental pulp pericytes are already precommitted to an odontoblast fate based on enrichment analysis indicating overrepresentation of key odontogenic genes. Furthermore, ChIP-seq analysis of the polycomb repressive complex 1 component RING1B indicated that this complex is likely to be involved in inhibiting inappropriate differentiation, as it localized to a number of loci of key transcription factors that are needed for the induction of adipogenesis, chondrogenesis, or myogenesis. In this review, we highlight recent data elucidating molecular mechanisms that indicate that pericytes can be ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1177/0022034519862258 |
| الإتاحة: | https://doi.org/10.1177/0022034519862258Test https://kclpure.kcl.ac.uk/portal/en/publications/658c7285-9c7d-4640-b870-c3a6d0baf81cTest https://kclpure.kcl.ac.uk/ws/files/113021544/Perivascular_Derived_Mesenchymal_Stem_YIANNI_Accepted18June2019Publishedonline5July2019_GREEN_AAM.pdfTest http://www.scopus.com/inward/record.url?scp=85068769468&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BB6919A8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0022034519862258 |
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