التفاصيل البيبلوغرافية
| العنوان: |
Comparison of breast cancer mucin (BCM) and CA 15-3 in human breast cancer |
| المؤلفون: |
Garcia, M.B., Blankenstein, M.A., Wall, E. van der, Nortier, J.W.R., Schornagel, J.H., Thijssen, J.H.H. |
| سنة النشر: |
1990 |
| مصطلحات موضوعية: |
Geneeskunde, BCM, breast cancer, CA 15-3, CEA, mucin, tumour markers |
| الوصف: |
The Breast Cancer Mucin (BCM) enzyme immunoassay utilizes two monoclonal antibodies (Mab), M85/34 and F36/22, for the identification of a mucin-like glycoprotein in serum of breast cancer patients. We have compared BCM with CA 15-3, another member of the human mammary epithelial antigen family. Serum BCM was evaluated in 151 and CA 15-3 in 134 patients with breast cancer, in 30 normal controls, in 9 pregnant women, and in 13 cancer patients (non-breast). Neither the normal controls nor the pregnant women had BCM levels > 25 U/ml. In contrast, 87 of 115 patients (75%) with metastatic breast cancer had BCM levels > 25 U/ml. All control persons had CA 15-3 levels < 25 U/ml, but 2 out of 9 pregnant women (22%) had levels > 25 U/ml. Seventy-four out of 97 patients (76%) with metastatic breast cancer had CA 15-3 levels > 25 U/ml. A statistically significant correlation was found between BCM and CA 15-3 in the breast cancer patient group (r = 0.883, p < 0.001, n = 134) and in the normal control group (r = 0.743, p < 0.001, n = 30). BCM and CA 15.3 both showed no correlation with CEA in breast cancer patients (r = 0.060, n = 81; and r = 0.146, n = 78, respectively). BCM had a range of sensitivity similar to that of the CA 15-3 RIA. Our results suggest that BCM may be a useful new marker for monitoring the clinical course of patients with breast cancer. Furthermore, in the evaluation of breast cancer patients, marker pands depending on disease stage may be a better choice than any single parameter in the evaluation of breast cancer patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
image/pdf |
| اللغة: |
English |
| تدمد: |
1573-7217 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/21584Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/21584Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.BB36CECA |
| قاعدة البيانات: |
BASE |
