دورية أكاديمية
Small nerve fiber damage and langerhans cells in type 1 and type 2 diabetes and LADA measured by corneal confocal microscopy
| العنوان: | Small nerve fiber damage and langerhans cells in type 1 and type 2 diabetes and LADA measured by corneal confocal microscopy |
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| المؤلفون: | D'Onofrio, Luca, Kalteniece, Alise, Ferdousi, Maryam, Azmi, Shazli, Petropoulos, Ioannis N., Ponirakis, Georgios, Alam, Uazman, Asghar, Omar, Marshall, Andrew, Boulton, Andrew J.M., Efron, Nathan, Buzzetti, Raffaella, Soran, Handrean, Malik, Rayaz A. |
| المصدر: | Investigative Ophthalmology and Visual Science |
| بيانات النشر: | Association for Research in Vision and Ophthalmology Inc. |
| سنة النشر: | 2021 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Corneal confocal microscopy, LADA, Langerhans cells, Type 1 diabetes, Type 2 diabetes |
| الوصف: | PURPOSE. Increased corneal and epidermal Langerhans cells (LCs) have been reported in patients with diabetic neuropathy. The aim of this study was to quantify the density of LCs in relation to corneal nerve morphology and the presence of diabetic neuropathy and to determine if this differed in patients with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and latent autoimmune diabetes of adults (LADA). METHODS. Patients with T1DM (n = 25), T2DM (n = 36), or LADA (n = 23) and control subjects (n = 23) underwent detailed assessment of peripheral neuropathy and corneal confocal microscopy. Corneal nerve fiber density (CNFD), branch density (CNBD), length (CNFL) and total, immature and mature LC densities were quantified. RESULTS. Lower CNFD (P < 0.001), CNBD (P < 0.0001), and CNFL (P < 0.0001) and higher LC density (P = 0.03) were detected in patients with T1DM, T2DM, and LADA compared to controls. CNBD was inversely correlated with mature (r = -0.5; P = 0.008), immature (r = -0.4; P = 0.02) and total (r = -0.5; P = 0.01) LC density, and CNFL was inversely correlated with immature LC density (r = -0.4; P = 0.03) in patients with T1DM but not in patients with T2DM and LADA. CONCLUSIONS. This study shows significant corneal nerve loss and an increase in LC density in patients with T1DM, T2DM, and LADA. Furthermore, increased LC density correlated with corneal nerve loss in patients with T1DM. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/230923/1/i1552_5783_62_6_5_1620039084.05569.pdfTest; D'Onofrio, Luca, Kalteniece, Alise, Ferdousi, Maryam, Azmi, Shazli, Petropoulos, Ioannis N., Ponirakis, Georgios, Alam, Uazman, Asghar, Omar, Marshall, Andrew, Boulton, Andrew J.M., Efron, Nathan, Buzzetti, Raffaella, Soran, Handrean, & Malik, Rayaz A. (2021) Small nerve fiber damage and langerhans cells in type 1 and type 2 diabetes and LADA measured by corneal confocal microscopy. Investigative Ophthalmology and Visual Science, 62(6), Article number: 5.; https://eprints.qut.edu.au/230923Test/; Faculty of Health; School of Optometry & Vision Science |
| الإتاحة: | https://doi.org/10.1167/IOVS.62.6.5Test https://eprints.qut.edu.au/230923Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; 2021 The Authors ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.BB1411AD |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |