دورية أكاديمية
Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity
| العنوان: | Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity |
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| المؤلفون: | Solana Balaguer, Júlia, Campoy Campos, Genís, Martín Flores, Núria, Pérez Sisqués, Leticia, Sitjà Roqueta, Laia, Kucukerden, Melike, Gámez Valero, Ana, Coll Manzano, Albert, Martí Puig, Eulàlia, Pérez Navarro, Esther, Alberch i Vié, Jordi, 1959-, Soriano i Fradera, Jordi, Masana Nadal, Mercè, Malagelada Grau, Cristina |
| المصدر: | Articles publicats en revistes (Física de la Matèria Condensada) |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2023 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Malalties neurodegeneratives, Neurones, Cèl·lules, Sinapsi, Sistema nerviós central, Comunicació, Neurodegenerative Diseases, Neurons, Cells, Synapses, Central nervous system, Communication |
| الوصف: | Extracellular vesicles (EVs) play an important role in intercellular communication as carriers of signalling molecules such as bioactive miRNAs, proteins and lipids. EVs are key players in the functioning of the central nervous system (CNS) by influencing synaptic events and modulating recipient neurons. However, the specific role of neuron-to-neuron communication via EVs is still not well understood. Here, we provide evidence that primary neurons uptake neuron-derived EVs in the soma, dendrites, and even in the dendritic spines, and carry synaptic proteins. Neuron-derived EVs increased spine density and promoted the phosphorylation of Akt and ribosomal protein S6 (RPS6), via TrkB-signalling, without impairing the neuronal network activity. Strikingly, EVs exerted a trophic effect on challenged nutrient-deprived neurons. Altogether, our results place EVs in the spotlight for synaptic plasticity modulation as well as a possible therapeutic tool to fight neurodegeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 18 p.; application/pdf |
| اللغة: | English |
| تدمد: | 2001-3078 |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.1002/jev2.12355Test; Journal Of Extracellular Vesicles, 2023, vol. 12, num.9; https://doi.org/10.1002/jev2.12355Test; http://hdl.handle.net/2445/206806Test; 739524 |
| الإتاحة: | https://doi.org/10.1002/jev2.12355Test http://hdl.handle.net/2445/206806Test |
| حقوق: | cc-by (c) Solana-Balaguer, J. et al., 2023 ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BADC0D38 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20013078 |
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