دورية أكاديمية
Association of systemic medication use with glaucoma and intraocular pressure: the E3 Consortium
| العنوان: | Association of systemic medication use with glaucoma and intraocular pressure: the E3 Consortium |
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| المؤلفون: | Vergroesen, Joëlle, E., Schuster, Alexander, K., Stuart, Kelsey, V., Asefa, Nigus, G., Cougnard-Grégoire, Audrey, Delcourt, Cécile, Schweitzer, Cédric, Barreto, Patrícia, Coimbra, Rita, Foster, Paul, J., Luben, Robert, N., Pfeiffer, Norbert, Stingl, Julia, V., Kirsten, Toralf, Rauscher, Franziska, G., Wirkner, Kerstin, Jansonius, Nomdo, M., Arnould, Louis, Creuzot‐garcher, Catherine, Stricker, Bruno, H., Keskini, Christina, Topouzis, Fotis, Bertelsen, Geir, Eggen, Anne, E., Bikbov, Mukharram, M., Jonas, Jost, B., Klaver, Caroline C.W., Ramdas, Wishal, D., Khawaja, Anthony, P., On Behalf of The European Eye Epidemiology (e3) Consortium, . |
| المساهمون: | Erasmus University Medical Center Rotterdam (Erasmus MC), University Medical Center of the Johannes Gutenberg-University Mainz, NHS Foundation Trust London, The Royal Marsden, University Medical Center Groningen Groningen (UMCG), Team MORPH3EUS (INSERM U1219 - UB - ISPED), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Association for Innovation and Biomedical Research on Light and Image (AIBILI), Leipzig University / Universität Leipzig, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université Bourgogne Franche-Comté COMUE (UBFC), Aristotle University of Thessaloniki, The Arctic University of Norway Tromsø, Norway (UiT), Ufa Eye Research Institute Bashkortostan, Université de Bordeaux (UB), University College of London London (UCL), CHU Dijon, Alienor study: Laboratoires Théa, Fondation Voir et Entendre, Agence Nationale de la Recherche, French Ministry of Health (PHRC 12_157, ECLAIR), CFSR Recherche (Club Français des Specialistes de la Retine). |
| المصدر: | ISSN: 0161-6420 ; Ophthalmology: Journal of The American Academy of Ophthalmology. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | systemic medication, glaucoma, intraocular pressure, epidemiology, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs |
| الوصف: | International audience ; PURPOSE: To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population. DESIGN: Meta-analysis of eleven population-based cohort studies of the European Eye Epidemiology (E3) consortium. PARTICIPANTS: A total of 143240 participants were included in the glaucoma analyses and 47177 participants in the IOP analyses. METHODS: We examined associations of four categories of systemic medications (antihypertensive medications: beta-blockers, diuretics, calcium channel blockers [CCBs], alpha-agonists, angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers; lipid-lowering medications; antidepressants; antidiabetic medications) with glaucoma prevalence and IOP. Glaucoma ascertainment and IOP measurement method were according to individual study protocols. Multivariable regression analyses were carried out in each study and results were pooled using random effects meta-analyses. Associations with antidiabetic medications were examined in diabetic participants only. MAIN OUTCOME MEASURES: Glaucoma prevalence and IOP. RESULTS: In the meta-analyses of our maximally-adjusted multivariable models, use of CCBs was associated with a higher prevalence of glaucoma (odds ratio [OR] with corresponding 95% confidence interval [95% CI]: 1.23 [1.08 to 1.39]). This association was stronger for monotherapy of CCBs with direct cardiac effects (OR [95% CI]: 1.96 [1.23 to 3.12]). The use of other antihypertensive medications, lipid-lowering medications, antidepressants or antidiabetic medications were not clearly associated with glaucoma. Use of systemic beta-blockers was associated with a lower IOP (Beta [95% CI]: -0.33 [-0.57 to -0.08] mmHg). Monotherapy of both selective (Beta [95% CI]: -0.45 [-0.74 to -0.16] mmHg) and non-selective (Beta [95% CI]: -0.54 [-0.94 to -0.15] mmHg) systemic beta-blockers was associated with lower IOP. There was a suggestive association between use of high-ceiling diuretics and lower IOP ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37150298; hal-04094139; https://hal.inrae.fr/hal-04094139Test; PII: S0161-6420(23)00306-8; PUBMED: 37150298; WOS: 001065958100001 |
| DOI: | 10.1016/j.ophtha.2023.05.001 |
| الإتاحة: | https://doi.org/10.1016/j.ophtha.2023.05.001Test https://hal.inrae.fr/hal-04094139Test |
| رقم الانضمام: | edsbas.BA9E4545 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ophtha.2023.05.001 |
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