التفاصيل البيبلوغرافية
| العنوان: |
The involvement of Toll‐like receptor 9 in the pathogenesis of erosive autoimmune arthritis |
| المؤلفون: |
Fischer, Anita, Abdollahi‐Roodsaz, Shahla, Böhm, Christina, Niederreiter, Birgit, Meyer, Brigitte, Yau, Anthony C. Y., Lönnblom, Erik, Joosten, Leo A. B., Koenders, Marije, Lehmann, Christian H. K., Dudziak, Diana, Krönke, Gerhard, Holmdahl, Rikard, Steiner, Günter |
| المساهمون: |
Seventh Framework Programme, Deutsche Forschungsgemeinschaft, Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg |
| المصدر: |
Journal of Cellular and Molecular Medicine ; volume 22, issue 9, page 4399-4409 ; ISSN 1582-1838 1582-4934 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2018 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Endogenous nucleic acids and their receptors may be involved in the initiation of systemic autoimmune diseases including rheumatoid arthritis ( RA ). As the role of the DNA sensing Toll‐like receptor ( TLR ) 9 in RA is unclear, we aimed to investigate its involvement in the pathogenesis of autoimmune arthritis using three different experimental models of RA . The data obtained revealed involvement of TLR 9 in the T cell‐dependent phase of inflammatory arthritis. In rats with pristane‐induced arthritis ( PIA ), TLR 9 inhibition before disease onset reduced arthritis significantly and almost completely abolished bone erosion. Accordingly, serum levels of IL ‐6, α‐1‐acid‐glycoprotein and rheumatoid factor were reduced. Moreover, in TLR 9 −/− mice, streptococcal cell wall (SCW)‐induced arthritis was reduced in the T cell‐dependent phase, whereas T cell‐independent serum‐transfer arthritis was not affected. Remarkably, while TLR 7 expression did not change during in vitro osteoclastogenesis, TLR 9 expression was higher in precursor cells than in mature osteoclasts and partial inhibition of osteoclastogenesis was achieved only by the TLR 9 antagonist. These results demonstrate a pivotal role for TLR 9 in the T cell‐dependent phases of inflammatory arthritis and additionally suggest some role during osteoclastogenesis. Hence, endogenous DNA seems to be crucially involved in the pathophysiology of inflammatory autoimmune arthritis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/jcmm.13735 |
| الإتاحة: |
https://doi.org/10.1111/jcmm.13735Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.BA957422 |
| قاعدة البيانات: |
BASE |
