التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference |
| المؤلفون: |
Wen, Wanqing, Kato, Norihiro, Hwang, Joo Yeon, Guo, Xingyi, Tabara, Yasuharu, Li, Huaixing, Dorajoo, Rajkumar, Yang, Xiaobo, Tsai, Fuu Jen, Li, Shengxu, Wu, Ying, Wu, Tangchun, Kim, Soriul, Guo, Xiuqing, Liang, Jun, Shungin, Dmitry, Adair, Linda S., Akiyama, Koichi, Allison, Matthew, Cai, Qiuyin, Chang, Li Ching, Chen, Chien Hsiun, Chen, Yuan Tsong, Cho, Yoon Shin, Choi, Bo Youl, Gao, Yutang, Go, Min Jin, Gu, Dongfeng, Han, Bok Ghee, He, Meian, Hixson, James E., Hu, Yanling, Huang, Tao, Isono, Masato, Jung, Keum Ji, Kang, Daehee, Kim, Young Jin, Kita, Yoshikuni, Lee, Juyoung, Lee, Nanette R., Lee, Jeannette, Wang, Yiqin, Liu, Jian Jun, Long, Jirong, Moon, Sanghoon, Nakamura, Yasuyuki, Nakatochi, Masahiro, Ohnaka, Keizo, Rao, Dabeeru, Shi, Jiajun, Sull, Jae Woong, Tan, Aihua, Ueshima, Hirotsugu, Wu, Chen, Xiang, Yong Bing, Yamamoto, Ken, Yao, Jie, Ye, Xingwang, Yokota, Mitsuhiro, Zhang, Xiaomin, Zheng, Yan, Qi, Lu, Rotter, Jerome I., Jee, Sun Ha, Lin, Dongxin, Mohlke, Karen L., He, Jiang, Mo, Zengnan, Wu, Jer Yuarn, Tai, E. Shyong, Lin, Xu, Miki, Tetsuro, Kim, Bong Jo, Takeuchi, Fumihiko, Zheng, Wei, Shu, Xiao Ou |
| المساهمون: |
田原, 康玄, 00268749 |
| بيانات النشر: |
Nature Publishing Group |
| سنة النشر: |
2016 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| الوصف: |
Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53, 052 (for WC) and 48, 312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3, 762 to 17, 110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2045-2322 |
| العلاقة: |
http://hdl.handle.net/2433/216138Test; Scientific Reports; 17958 |
| الإتاحة: |
http://hdl.handle.net/2433/216138Test |
| حقوق: |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.BA37E81F |
| قاعدة البيانات: |
BASE |
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