دورية أكاديمية
Radiotherapy in elderly patients with breast cancer: a literature review of acute and late toxicity
| العنوان: | Radiotherapy in elderly patients with breast cancer: a literature review of acute and late toxicity |
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| المؤلفون: | Alice Zamagni, Milly Buwenge, Ilario Ammendolia, Martina Ferioli, Anna Mandrioli, Alessio G. Morganti, Silvia Cammelli |
| المساهمون: | Alice Zamagni, Milly Buwenge, Ilario Ammendolia, Martina Ferioli, Anna Mandrioli, Alessio G. Morganti, Silvia Cammelli |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Breast cancer, elderly patient, radiotherapy, toxicity |
| الوصف: | Radiotherapy (RT) induced toxicity in elderly patients is not well documented in the available literature due to the inhomogeneous and fragmentary data. Aim of this study was to review literature data on acute and late toxicity in elderly breast cancer patients treated with RT. The primary endpoint was RT-related acute and late toxicity in elderly breast cancer (BC) patients. The secondary endpoint was RT interruption rate in this patients’ population. All studies reporting RT-related acute and/or late toxicity in elderly women with breast cancer were included. All types of RT settings were included and no restriction was applied regarding other primary/adjuvant associated treatment. A bibliographic search was performed on PubMed. Only articles in English were considered while no chronological limitation was applied. Twentytwo studies were included in this analysis: 12 retrospective, 5 prospective observational trials, 1 phase III trial sub-analysis, and 4 phase I-II trials. Thirteen studies reported results about whole breast irradiation (WBI) delivered by external beams (EB) RT ± boost on the tumor bed. Nine studies reported results about accelerated partial breast irradiation (APBI) based on EB RT (2 studies), intraoperative RT (IORT: 2 studies), and brachytherapy (BRT: 2 studies); three studies compared different treatment techniques. Overall, reported acute grade (G) ≥3 toxicity ranged from 0.0% to 10.5% and late toxicity from 0.0% to 13.0%. RT discontinuation/interruption rates ranged between 0.0% and 2.0%. Acute G ≥3 toxicity rates were 2.0%, 6.7%, and 5.2% with EB-APBI, BRT, and IORT, respectively. Late G ≥3 toxicity with EB-APBI was 2.8%. No late G ≥3 toxicity was recorded in studies reporting on BRT and IORT. With WBI, the overall rates of G ≥3 toxicity were 3.0% (acute) and 1.8% (late). Higher toxicity rates were observed with weekly hypofractionation. None of the studies directly comparing age subgroups found age-related differences. Our findings suggest that RT of breast cancer is well tolerated ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000507394100022; volume:9; issue:1; firstpage:173; lastpage:188; numberofpages:16; journal:TRANSLATIONAL CANCER RESEARCH; https://hdl.handle.net/11585/711307Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078991861; Radiotherapy in elderly patients with breast cancer: a literature review of acute and late toxicity |
| DOI: | 10.21037/tcr.2019.08.28 |
| الإتاحة: | https://doi.org/10.21037/tcr.2019.08.28Test https://hdl.handle.net/11585/711307Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B9FCF93B |
| قاعدة البيانات: | BASE |
| DOI: | 10.21037/tcr.2019.08.28 |
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