دورية أكاديمية
Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults
| العنوان: | Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults |
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| المؤلفون: | Pronk, A. C., Seppala, L. J., Trajanoska, K., Stringa, N., van de Loo, B., de Groot, L. C.P.G.M., van Schoor, N. M., Koskeridis, F., Markozannes, G., Ntzani, E., Uitterlinden, A. G., Rivadeneira, F., Stricker, B. H., van der Velde, N. |
| المصدر: | Pronk , A C , Seppala , L J , Trajanoska , K , Stringa , N , van de Loo , B , de Groot , L C P G M , van Schoor , N M , Koskeridis , F , Markozannes , G , Ntzani , E , Uitterlinden , A G , Rivadeneira , F , Stricker , B H & van der Velde , N 2022 , ' Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults ' , PLoS ONE , vol. 17 , no. 4 April , e0266590 . .... |
| سنة النشر: | 2022 |
| الوصف: | Background Antidepressant use has been associated with increased fall risk. Antidepressant-related adverse drug reactions (e.g. orthostatic hypotension) depend partly on genetic variation. We hypothesized that candidate genetic polymorphisms are associated with fall risk in older antidepressant users. Methods The association between antidepressant use and falls was cross-sectionally investigated in a cohort of Dutch older adults by logistic regression analyses. In case of significant interaction product term of antidepressant use and candidate polymorphism, the association between the variant genotype and fall risk was assessed within antidepressant users and the association between antidepressant use and fall risk was investigated stratified per genotype. Secondly, a look-up of the candidate genes was performed in an existing genome-wide association study on drug-related falls in antidepressant users within the UK Biobank. In antidepressant users, genetic associations for our candidate polymorphisms for fall history were investigated. Results In antidepressant users(n = 566), for rs28371725 (CYP2D6*41) fall risk was decreased in TC/variant allele carriers compared to CC/non-variant allele carriers (OR = 0.45, 95% CI 0.26–0.80). Concerning rs1057910 (CYP2C9*3), fall risk was increased in CA/variant allele carriers compared to AA/non-variant allele carriers (OR = 1.95, 95% CI 1.17–3.27). Regarding, rs1045642 (ABCB1), fall risk was increased in AG/variant allele carriers compared to GG/non-variant allele carriers (OR = 1.69, 95% CI 1.07–2.69). Concerning the ABCB1-haplotype (rs1045642/rs1128503), fall risk was increased in AA-AA/variant allele carriers compared to GG-GG/non-variant allele carriers (OR = 1.86, 95% CI 1.05–3.29). In the UK Biobank, in antidepressant users(n = 34,000) T/variant-allele of rs28371725 (CYP2D*41) was associated with increased fall risk (OR = 1.06, 95% CI 1.01–1.12). G/non-variant-allele of rs4244285 (CY2C19*2) was associated with decreased risk (OR = 0.96, 95% CI 0.92–1.00). Conclusion ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/d3fa0754-1d13-4ff0-b4e1-60eec1f4f0e3Test |
| DOI: | 10.1371/journal.pone.0266590 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0266590Test https://pure.eur.nl/en/publications/d3fa0754-1d13-4ff0-b4e1-60eec1f4f0e3Test https://pure.eur.nl/ws/files/83231298/journal.pone.0266590.pdfTest http://www.scopus.com/inward/record.url?scp=85128271657&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B9D6C424 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0266590 |
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