دورية أكاديمية

NEW METHODS FOR PRETERM BIRTH PREDICTION: THE PAMG-1 TEST

التفاصيل البيبلوغرافية
العنوان: NEW METHODS FOR PRETERM BIRTH PREDICTION: THE PAMG-1 TEST
المؤلفون: DI FABRIZIO, LAURA, Irene GIARDINA, Irene CETIN, Mariarosaria DI TOMMASO, CIAVATTINI, ANDREA, Mariavittoria LOCCI, Fabio FACCHINETTI, Marina ZONCA, Gian Carlo DI RENZO
المساهمون: DI FABRIZIO, Laura, Giardina, Irene, Irene, Cetin, Mariarosaria DI TOMMASO, Ciavattini, Andrea, Mariavittoria, Locci, Fabio, Facchinetti, Marina, Zonca, DI RENZO, Giancarlo
سنة النشر: 2018
المجموعة: IRIS Università degli Studi di Perugia
مصطلحات موضوعية: Cervical length measurement, Human IGFBP1 protein, Premature birth, Premature obstetric labor
الوصف: BACKGROUND: The aim of this study was to assess the efficacy of PAMG-1 test (placental alpha microglobulin-1) in cervicovaginal secretions collected immediately following transvaginal ultrasound (TVUS) of women with signs and symptoms of preterm labor (PTL), clinically intact membranes and cervical length between 15 and 30 mm for the prediction of imminent spontaneous delivery (within 7 days of testing), as well as delivery <34 weeks of gestation.METHODS: Performing PAMG-1 test in 79 women with singleton pregnancy (24(0/7)-33(6/7) weeks' gestation) reporting signs and symptoms indicative of IPTI, and cervical length <30 mm.RESULTS: For PTB prediction risk within 7 days of testing in pregnant women with cervicale length between 15-30 mm sensitivity is 100% and specificity is 94%. Positive predictive value (PPV) is 77% and negative predictive value (NPV) is 100%. For delivery prediction <34 weeks of gestation sensitivity decreased from 100% to 67% and specificity from 94% to 89%, PPV is 55% and NPV 93%.CONCLUSIONS: The inaccuracy of traditional methods, including biophysical tests, biochemical markers, or the combination of both, for assessing the risk of spontaneous pretenn birth in patients presenting with symptoms of PTL often leads to unnecessary admission and administration of corticosteroids and tocolytics. The PAMG-1 test demonstrated high efficacy in identifying women at risk of imminent PTL within 7 days of testing, despite being performed immediately after TVUS. High NPV can prevent improper admission and unnecessary therapies for mother and fetus.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: Portuguese
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29856188; info:eu-repo/semantics/altIdentifier/wos/WOS:000456056700012; volume:70; issue:5; firstpage:635; lastpage:640; numberofpages:6; journal:MINERVA GINECOLOGICA; http://hdl.handle.net/11391/1438058Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85051645688; https://www.minervamedica.it/en/getpdf/iQp4Gh5SecPvAdJFmHgntEIQxAsYRpUi4ifFTMxBSnnvNSoegOvAonw5FJkLf7tJOIUlXK8Gn78L%252FMV21AA9VA%253D%253D/R09Y2018N05A0635.pdfTest
DOI: 10.23736/S0026-4784.18.04243-0
الإتاحة: https://doi.org/10.23736/S0026-4784.18.04243-0Test
http://hdl.handle.net/11391/1438058Test
https://www.minervamedica.it/en/getpdf/iQp4Gh5SecPvAdJFmHgntEIQxAsYRpUi4ifFTMxBSnnvNSoegOvAonw5FJkLf7tJOIUlXK8Gn78L%252FMV21AA9VA%253D%253D/R09Y2018N05A0635.pdfTest
رقم الانضمام: edsbas.B9932ECF
قاعدة البيانات: BASE