دورية أكاديمية
Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study)
| العنوان: | Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study) |
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| المؤلفون: | Bayram F., Sonmez A., Haymana C., Sabuncu T., Dizdar O.S., Gurkan E., Carlioglu A.K. |
| بيانات النشر: | BioMed Central Ltd |
| سنة النشر: | 2020 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Dyslipidemia, Lipid-lowering treatments, Low-density lipoprotein cholesterol target attainment, Physician inertia, Physicians’ attitudes, Statin cessation, Type 2 diabetes mellitus, hemoglobin A1c, hydroxymethylglutaryl coenzyme A reductase inhibitor, low density lipoprotein cholesterol, glycosylated hemoglobin, hemoglobin A1c protein, human, adult, anthropometry, Article, cross-sectional study, diabetic nephropathy, disease duration, drug utilization, female, follow up, major clinical study, male, non insulin dependent diabetes mellitus, outpatient department, self report, tertiary care center, Turk (people), Turkey (republic) |
| الوصف: | Background: Attaining acceptable levels of LDL Cholesterol (LDL-C) significantly improves cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (T2DM). The LDL-C target attainment and the characteristics of patients attaining these targets were investigated in this study. Furthermore, the reasons for not choosing statins and the physicians’ attitudes on the treatment of diabetic dyslipidemia were also examined. Methods: A nationwide, cross-sectional survey was conducted in tertiary centers for diabetes management. Adult patients with T2DM, who were under follow-up for at least a year in outpatient clinics, were consecutively enrolled for the study. LDL-C goals were defined as below 70 mg/dL for patients with macrovascular complications or diabetic nephropathy, and below 100 mg/dL for other patients. Data about lipid-lowering medications were self-reported. Results: A total of 4504 patients (female: 58.6%) were enrolled for the study. The mean HbA1c and diabetes duration was 7.73 ± 1.74% and 10.9 ± 7.5 years, respectively. The need for statin treatment was 94.9% (n = 4262); however, only 42.4% (n = 1807) of these patients were under treatment, and only 24.8% (n = 448) of these patients achieved LDL-C targets. The main reason for statin discontinuation was negative media coverage (87.5%), while only a minority of patients (12.5%) mentioned side effects. Physicians initiated lipid-lowering therapy in only 20.3% of patients with high LDL-C levels. It was observed that the female gender was a significant independent predictor of not attaining LDL-C goals (OR: 0.70, 95% CI: 0.59–0.83). Conclusions: Less than 50 % of patients with T2DM who need statins were under treatment, and only a quarter of them attained their LDL-C targets. There exists a significant gap between the guideline recommendations and the real-world evidence in the treatment of dyslipidemia in T2DM. © 2020, The Author(s). ; Ankara Universitesi; University of Health Sciences Lahore, UHS ; The physicians and nurses in every TEMD study ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476511X |
| العلاقة: | Lipids in Health and Disease; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1186/s12944-020-01408-2Test; https://hdl.handle.net/11454/79742Test; 19; 2-s2.0-85095847674 |
| DOI: | 10.1186/s12944-020-01408-2 |
| الإتاحة: | https://doi.org/10.1186/s12944-020-01408-2Test https://hdl.handle.net/11454/79742Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B937CA35 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1476511X |
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| DOI: | 10.1186/s12944-020-01408-2 |