دورية أكاديمية
Repression of autocrine pheromone signaling leads to fusaric acid over-production ...
| العنوان: | Repression of autocrine pheromone signaling leads to fusaric acid over-production ... |
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| المؤلفون: | Staropoli, Alessia, Guastaferro, Valentino Maria, Vinale, Francesco, Turrà, David, Di Costanzo, Luigi, Vitale, Stefania |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Biochemistry, Microbiology, FOS Biological sciences, Genetics, Molecular Biology, Neuroscience, Pharmacology, Chemical Sciences not elsewhere classified, Ecology, Infectious Diseases, FOS Health sciences, Plant Biology |
| الوصف: | Fusaric acid (FA), a picolinic acid derivative, is a natural substance produced by a wide variety of fungal plant pathogens belonging to the Fusarium genus. As a metabolite, fusaric acid exerts several biological activities including metal chelation, electrolyte leakage, repression of ATP synthesis, and direct toxicity on plants, animals and bacteria. Prior studies on the structure of fusaric acid revealed a co-crystal dimeric adduct between FA and 9,10-dehydrofusaric acid. During an ongoing search for signaling genes differentially regulating FA production in the fungal pathogen Fusarium oxysporum ( Fo ), we found that mutants lacking pheromone expression have an increased production of FA compared to the wild type strain. Noteworthy, crystallographic analysis of FA extracted from Fo culture supernatants showed that crystals are formed by a dimeric form of two FA molecules (1:1 molar stoichiometry). Overall, our results suggest that pheromone signaling in Fo is required to regulate the synthesis of fusaric ... |
| نوع الوثيقة: | text other non-article part of journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://dx.doi.org/10.6084/m9.figshare.23617706Test; https://dx.doi.org/10.1080/14786419.2023.2227992Test |
| DOI: | 10.6084/m9.figshare.23617706.v2 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.23617706.v210.6084/m9.figshare.2361770610.1080/14786419.2023.2227992Test https://tandf.figshare.com/articles/journal_contribution/Repression_of_autocrine_pheromone_signaling_leads_to_fusaric_acid_over-production/23617706/2Test |
| حقوق: | Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 |
| رقم الانضمام: | edsbas.B8596F95 |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.23617706.v2 |
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