دورية أكاديمية
أعرض في EDS

Case report: A successful second autologous hematopoietic stem cell transplantation in refractory systemic sclerosis, with positive effect on skin involvement, pulmonary function and microcirculation

التفاصيل البيبلوغرافية
العنوان: Case report: A successful second autologous hematopoietic stem cell transplantation in refractory systemic sclerosis, with positive effect on skin involvement, pulmonary function and microcirculation
المؤلفون: Haverkort, D A, Kersten, B E, van Rhenen, A, van der Velden, W J F M, Vonk, M C
المساهمون: MS Hematologie, Cancer
سنة النشر: 2022
مصطلحات موضوعية: interstitial lung disease, microvascular abnormalities, nailfod capillaroscopy, Rodnan skin score, stem cell transplant (SCT), systemic sclerosis, Immunology and Allergy, Immunology, Case Reports
الوصف: BACKGROUND: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by inflammation, vasculopathy and fibrosis of the skin and internal organs. Treatment with autologous hematopoietic cell transplantation (HCT) for progressive SSc has improved overall and event-free survival rates significantly, but unfortunately disease progression after HCT is seen in a subset of patients. Data on the efficacy and safety of second HCT is scarce. CASE: We present a patient with diffuse cutaneous SSc and associated interstitial lung disease (ILD) who successfully underwent a second HCT for progressive disease five years after a first HCT. We describe changes in skin involvement and pulmonary involvement as well as the changes observed in sequential nailfold microcapillaroscopy (NCM), performed from first presentation up to this moment. CONCLUSION: This case adds to the current limited literature on efficacy and safety of a second HCT in SSc refractory cases. Furthermore it outlines the potential of HCT on amelioration of microvasculopathy in SSc.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1664-3224
العلاقة: https://dspace.library.uu.nl/handle/1874/447906Test
الإتاحة: https://dspace.library.uu.nl/handle/1874/447906Test
حقوق: info:eu-repo/semantics/OpenAccess
رقم الانضمام: edsbas.B7AC6CA1
قاعدة البيانات: BASE
الوصف
تدمد:16643224