دورية أكاديمية
Debilitating Darier's disease
| العنوان: | Debilitating Darier's disease |
|---|---|
| المؤلفون: | Brodell, David W., Washington University in St. Louis, St. Louis, MO, USA, Frisch, Lawrence E., Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, USA, Brodell, Robert, Northeastern Ohio Universities, College of Medicine, Rootstown, Ohio, Case Western Reserve, School of Medicine, Cleveland, Ohio, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA, rtb@neoucom.edu |
| المصدر: | SIGNA VITAE (julije.mestrovic@signavitae.com); Vol.2 No.1 |
| بيانات النشر: | Pharmamed Mado Ltd. |
| سنة النشر: | 2007 |
| المجموعة: | Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| مصطلحات موضوعية: | Darier's Disease, ace-tretin, inherited dermatoses |
| الوصف: | Darier's disease is an inherited dermatitis that is due to a mutation in the ATP2A2 gene. This mutation causes disrupted signaling within cells and leads to a skin condition that is resistant to many dermatologic treatments. Though serious complications are rare, Darier's disease can result in bacterial sepsis and Kaposi's varicelliform eruption. In some families seizure disorders are linked to Darier's disease. There is also a paraneoplastic variant that could be considered in patients without a family history of Darier's disease. This article reports a case with typical verrucous masses and waxy papules which, over twenty years, became disabling. Symptoms included pruritus and foul odor and were relieved, along with the keratotic rash, utilizing systemic treatment with acitretin though the condition recurred rapidly when treatment was interrupted. Darier's disease must be considered when patients present with hyperkeratotic lesions that are resistant to usual forms of therapy for inflammatory dermatoses. |
| نوع الوثيقة: | text |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | http://hrcak.srce.hr/11969Test; http://hrcak.srce.hr/file/18415Test |
| الإتاحة: | http://hrcak.srce.hr/11969Test http://hrcak.srce.hr/file/18415Test |
| حقوق: | The publisher reserves all rights. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any other technically available means, without prior written permission from the publisher. The data, opinions and statements appearing in the articles herein are those of the contributors concerned, such opinions are not necessarily shared by the editor or the editorial board. Accordingly, the publisher, editor and editorial board accept no liability for the consequences of any such inaccurate or misleading data, opinions or statements. |
| رقم الانضمام: | edsbas.B7833634 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |