دورية أكاديمية
Evaluation of 311 contemporary cases of stereotactic biopsies in patients with neoplastic and non-neoplastic lesions—diagnostic yield and management of non-diagnostic cases
| العنوان: | Evaluation of 311 contemporary cases of stereotactic biopsies in patients with neoplastic and non-neoplastic lesions—diagnostic yield and management of non-diagnostic cases |
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| المؤلفون: | Pasternak, Krystyna Agnieszka, Schwake, Michael, Warneke, Nils, Masthoff, Max, Zawy Alsofy, Samer, Suero Molina, Eric, Stummer, Walter, Schipmann, Stephanie |
| المصدر: | http://lobid.org/resources/99370671253306441Test#!, 44(5):2597-2609. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Glioma, Non-diagnostic biopsy, Adult [MeSH], Biopsy [MeSH], Vasculitis, Humans [MeSH], Stereotactic biopsy, Stereotaxic Techniques [MeSH], Retrospective Studies [MeSH], Brain lesion, Brain [MeSH], Original Article, Brain Neoplasms/diagnosis [MeSH], Diagnostic yield |
| الوصف: | Stereotactic biopsies are an established tool for obtaining diagnosis of unclear brain lesions. However, non-diagnostic biopsies still occur. We aimed to analyze the contemporary diagnostic yield of stereotactic biopsies, predictors for non-diagnostic biopsies, outcome, and follow-up strategy after non-diagnostic biopsy. We conducted a single-center retrospective study of 311 adult patients undergoing stereotactic biopsies due to a newly diagnosed lesion at our department between 2012 and 2018. Patient data regarding comorbidities, presenting symptoms, imaging features, and non-invasive diagnostic procedures were obtained. The overall diagnostic yield was 86.2% and differed significantly between the various suspected diagnosis groups and was the highest when suspecting primary brain tumor compared with non-neoplastic lesions (91.2% vs. 73.3%, p > 0.001). Predicators for non-diagnostic biopsies were small lesion size, lack of contrast-enhancement, presence of sepsis, or underlying hemato-oncological disease. In case of non-diagnostic biopsy, a re-biopsy was performed in 12 cases, revealing a final diagnosis in 75%. In 16 cases, empiric therapy was started based on the suspected underlying disease. Close follow-up was performed in the remaining 15 cases. We showed that stereotactic biopsy is a safe procedure with reasonable diagnostic yield even for non-neoplastic lesions, when non-invasive diagnostic was inconclusive. In addition, we developed treatment recommendations for cases of non-diagnostic biopsies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6470562Test; https://doi.org/10.1007/s10143-020-01394-0Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490258Test/ |
| DOI: | 10.1007/s10143-020-01394-0 |
| الإتاحة: | https://doi.org/10.1007/s10143-020-01394-0Test https://repository.publisso.de/resource/frl:6470562Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490258Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.B77E3DB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10143-020-01394-0 |
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