التفاصيل البيبلوغرافية
| العنوان: |
Table_2_Identification and Analysis of SARS-CoV-2 Alpha Variants in the Largest Taiwan COVID-19 Outbreak in 2021.DOCX |
| المؤلفون: |
Li-Teh Liu, Jih-Jin Tsai, Ko Chang, Chun-Hong Chen, Ping-Chang Lin, Ching-Yi Tsai, Yan-Yi Tsai, Miao-Chen Hsu, Wan-Long Chuang, Jer-Ming Chang, Shang-Jyh Hwang, Inn-Wen Chong |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Dermatology, Emergency Medicine, Gastroenterology and Hepatology, Geriatrics and Gerontology, Intensive Care, Medical Genetics (excl. Cancer Genetics), Nephrology and Urology, Nuclear Medicine, Orthopaedics, Otorhinolaryngology, Pathology (excl. Oral Pathology), Radiology and Organ Imaging, Foetal Development and Medicine, Obstetrics and Gynaecology, Family Care, Primary Health Care, Medical and Health Sciences not elsewhere classified, COVID-19, SARS-CoV-2, qRT-PCR, virus culture, next-generation sequencing, clade replacements, phylogenetic analysis, alpha/B.1.1.7 |
| الوصف: |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to have originated in Wuhan City, Hubei Province, China, in December 2019. Infection with this highly dangerous human-infecting coronavirus via inhalation of respiratory droplets from SARS-CoV-2 carriers results in coronavirus disease 2019 (COVID-19), which features clinical symptoms such as fever, dry cough, shortness of breath, and life-threatening pneumonia. Several COVID-19 waves arose in Taiwan from January 2020 to March 2021, with the largest outbreak ever having a high case fatality rate (CFR) (5.95%) between May and June 2021. In this study, we identified five 20I (alpha, V1)/B.1.1.7/GR SARS-CoV-2 (KMUH-3 to 7) lineage viruses from COVID-19 patients in this largest COVID-19 outbreak. Sequence placement analysis using the existing SARS-CoV-2 phylogenetic tree revealed that KMUH-3 originated from Japan and that KMUH-4 to KMUH-7 possibly originated via local transmission. Spike mutations M1237I and D614G were identified in KMUH-4 to KMUH-7 as well as in 43 other alpha/B.1.1.7 sequences of 48 alpha/B.1.1.7 sequences deposited in GISAID derived from clinical samples collected in Taiwan between 20 April and July. However, M1237I mutation was not observed in the other 12 alpha/B.1.1.7 sequences collected between 26 December 2020, and 12 April 2021. We conclude that the largest COVID-19 outbreak in Taiwan between May and June 2021 was initially caused by the alpha/B.1.1.7 variant harboring spike D614G + M1237I mutations, which was introduced to Taiwan by China Airlines cargo crew members. To our knowledge, this is the first documented COVID-19 outbreak caused by alpha/B.1.1.7 variant harboring spike M1237I mutation thus far. The largest COVID-19 outbreak in Taiwan resulted in 13,795 cases and 820 deaths, with a high CFR, at 5.95%, accounting for 80.90% of all cases and 96.47% of all deaths during the first 2 years. The high CFR caused by SARS-CoV-2 alpha variants in Taiwan can be attributable to comorbidities and low herd immunity. We also ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_2_Identification_and_Analysis_of_SARS-CoV-2_Alpha_Variants_in_the_Largest_Taiwan_COVID-19_Outbreak_in_2021_DOCX/22893023Test |
| DOI: |
10.3389/fmed.2022.869818.s005 |
| الإتاحة: |
https://doi.org/10.3389/fmed.2022.869818.s005Test
https://figshare.com/articles/dataset/Table_2_Identification_and_Analysis_of_SARS-CoV-2_Alpha_Variants_in_the_Largest_Taiwan_COVID-19_Outbreak_in_2021_DOCX/22893023Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.B7637794 |
| قاعدة البيانات: |
BASE |
