التفاصيل البيبلوغرافية
| العنوان: |
Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis |
| المؤلفون: |
Sobkowiak, Paulina, Narożna, Beata, Wojsyk-Banaszak, Irena, Bręborowicz, Anna, Szczepankiewicz, Aleksandra |
| المساهمون: |
Narodowe Centrum Nauki, uniwersytet medyczny im. karola marcinkowskiego w poznaniu, the National Science Centre in Poland |
| المصدر: |
International Journal of Immunopathology and Pharmacology ; volume 35, page 205873842199049 ; ISSN 2058-7384 2058-7384 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2021 |
| الوصف: |
Allergic rhinitis (AR) and allergic asthma (AA) exhibit similar inflammatory response in the airways. However, the remodelling is more extensive in the lower airways, suggesting that the inflammation itself is not sufficient for allergic phenotype. We aimed to analyse whether the expression of selected 27 inflammatory and fibrosis-related proteins may be altered in AR and AA in the paediatric population and whether the expression pattern is either similar (due to the inflammation) or disease-specific (due to the remodelling). We analysed 80 paediatric subjects: 39 with AA, 21 with AR and 20 healthy children. The diagnosis of AR and AA was based on clinical manifestation, lung function, positive skin prick tests and increased immunoglobulin E levels. Serum levels of selected inflammatory proteins were measured with custom Magnetic Luminex Assay. Statistical analysis was performed in Statistica v.13. CCL2/MCP1, GM-CSF, gp130 and periostin concentrations were significantly lower, whereas IL-5 levels were higher in AA compared to the control group. CD-40L, CHI3L1/YKL-40, EGF, GM-CSF and periostin levels were significantly decreased in patients with AR than in the control group. Comparison of AA and AR patients revealed significant changes in CHI3L1/YKL-40 ( P = 0.021), IL-5 ( P = 0.036), periostin ( P = 0.013) and VEGFα ( P = 0.046). Significantly altered proteins were good predictors to distinguish between AA and AR ( P < 0.001, OR 46.00, accuracy 88.57%). Our results suggest that the expression of four fibrotic proteins was significantly altered between AA and AR, suggesting possible differences in airway remodelling between upper and lower airways. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/2058738421990493 |
| الإتاحة: |
https://doi.org/10.1177/2058738421990493Test |
| حقوق: |
https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.B75EFB18 |
| قاعدة البيانات: |
BASE |
