دورية أكاديمية
A genome-wide association study of the longitudinal course of executive functions
| العنوان: | A genome-wide association study of the longitudinal course of executive functions |
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| المؤلفون: | Wendel, B, Papiol, S, Andlauer, TFM, Zimmermann, J, Wiltfang, J, Spitzer, C, Senner, F, Schulte, EC, Schmauss, M, Schaupp, SK, Repple, J, Reininghaus, E, Reimer, J, Reich-Erkelenz, D, Opel, N, Meinert, S, Konrad, C, Kloehn-Saghatolislam, F, Kircher, T, Kalman, JL, Juckel, G, Jansen, A, Jaeger, M, Heilbronner, M, von Hagen, M, Gade, K, Figge, C, Fallgatter, AJ, Dietrich, DE, Dannlowski, U, Comes, AL, Budde, M, Baune, BT, Arolt, V, Anghelescu, I-G, Anderson-Schmidt, H, Adorjan, K, Falkai, P, Schulze, TG, Bickeboeller, H, Heilbronner, U |
| بيانات النشر: | SPRINGERNATURE |
| سنة النشر: | 2021 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Executive functions are metacognitive capabilities that control and coordinate mental processes. In the transdiagnostic PsyCourse Study, comprising patients of the affective-to-psychotic spectrum and controls, we investigated the genetic basis of the time course of two core executive subfunctions: set-shifting (Trail Making Test, part B (TMT-B)) and updating (Verbal Digit Span backwards) in 1338 genotyped individuals. Time course was assessed with four measurement points, each 6 months apart. Compared to the initial assessment, executive performance improved across diagnostic groups. We performed a genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with performance change over time by testing for SNP-by-time interactions using linear mixed models. We identified nine genome-wide significant SNPs for TMT-B in strong linkage disequilibrium with each other on chromosome 5. These were associated with decreased performance on the continuous TMT-B score across time. Variant rs150547358 had the lowest P value = 7.2 × 10-10 with effect estimate beta = 1.16 (95% c.i.: 1.11, 1.22). Implementing data of the FOR2107 consortium (1795 individuals), we replicated these findings for the SNP rs150547358 (P value = 0.015), analyzing the difference of the two available measurement points two years apart. In the replication study, rs150547358 exhibited a similar effect estimate beta = 0.85 (95% c.i.: 0.74, 0.97). Our study demonstrates that longitudinally measured phenotypes have the potential to unmask novel associations, adding time as a dimension to the effects of genomics. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2158-3188 |
| العلاقة: | pii: 10.1038/s41398-021-01510-8; Wendel, B., Papiol, S., Andlauer, T. F. M., Zimmermann, J., Wiltfang, J., Spitzer, C., Senner, F., Schulte, E. C., Schmauss, M., Schaupp, S. K., Repple, J., Reininghaus, E., Reimer, J., Reich-Erkelenz, D., Opel, N., Meinert, S., Konrad, C., Kloehn-Saghatolislam, F., Kircher, T. ,. Heilbronner, U. (2021). A genome-wide association study of the longitudinal course of executive functions. TRANSLATIONAL PSYCHIATRY, 11 (1), https://doi.org/10.1038/s41398-021-01510-8Test.; http://hdl.handle.net/11343/304952Test |
| الإتاحة: | https://doi.org/10.1038/s41398-021-01510-8Test http://hdl.handle.net/11343/304952Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.B6F6ED5D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21583188 |
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