دورية أكاديمية
HIGH DOSE-RATE BRACHYTHERAPY OF LOCALIZED PROSTATE CANCER CONVERTS TUMORS FROM COLD TO HOT
| العنوان: | HIGH DOSE-RATE BRACHYTHERAPY OF LOCALIZED PROSTATE CANCER CONVERTS TUMORS FROM COLD TO HOT |
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| المؤلفون: | Keam, S, Halse, H, ThuNgoc, N, Wang, M, Losio, NVK, Mitchell, C, Caramia, F, Byrne, D, Haupt, S, Ryland, G, Darcy, P, Sandhu, S, Blombery, P, Haupt, Y, Williams, S, Neeson, P |
| المصدر: | 35th Anniversary Annual Meeting (SITC 2020) |
| بيانات النشر: | BMJ PUBLISHING GROUP |
| سنة النشر: | 2020 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Background Prostate cancer is frequently cured with high dose-rate brachytherapy (HDRBT) radiation as a front-line treatment. Although considered to be an immune-excluded tissue, immune responses to radiation are implicated in driving tumour-eradication in prostate cancer.1 This has not been proven, and yet is used as the rationale for clinical trials combining radiation and immunotherapies.2 We hypothesise that there is a predictable relationship between radiation and the immune responses in prostate cancer that could be used to provide sound rationale for specific immune interventions in solid tumours that are made possible by radiation therapy. Methods We present here new results stemming from our recently published immunoprofiling study of world-unique pre- and post-radiation tissues from 24 prostate cancer patients (figure 1A), RadBank cohort).3 These samples were assessed using immune cell multiplex IHC, gene expression profiling, digital spatial profiling (DSP) and computational analysis of cell distribution. Results This study unequivocally revealed that high dose-rate radiation converts predominately ‘cold’ prostate tumour tissue to a more activated ‘hot’ state comprised of two sub-types (high and a less activated intermediate state). These changes were evident in increased tumour inflammation gene signatures and immune checkpoint expression, immune cell composition changes, and alterations in spatial interactions. However, as 20% of the patients did not respond, we also explored pre-treatment gene signatures of patient responses to radiation – identifying potential mechanisms that prime tissues to respond more favourably. Most recently, we have explored three other important facets of the immune response to HDRBT: (i) putative differential drivers of high and intermediate responses (figure 1B), (ii) TCR clonality changes (figure 1C), and (iii) the influence of clinical features (e.g. Gleason grade) and treatment (e.g. androgen deprivation) (figure 1D). Differential expression analysis has identified ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2051-1426 |
| العلاقة: | Keam, S., Halse, H., ThuNgoc, N., Wang, M., Losio, N. V. K., Mitchell, C., Caramia, F., Byrne, D., Haupt, S., Ryland, G., Darcy, P., Sandhu, S., Blombery, P., Haupt, Y., Williams, S. & Neeson, P. (2020). HIGH DOSE-RATE BRACHYTHERAPY OF LOCALIZED PROSTATE CANCER CONVERTS TUMORS FROM COLD TO HOT. [Abstract]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 8 (Suppl 3), pp.A347-A348. https://doi.org/10.1136/jitc-2020-SITC2020.0580Test.; http://hdl.handle.net/11343/280502Test |
| الإتاحة: | https://doi.org/10.1136/jitc-2020-SITC2020.0580Test http://hdl.handle.net/11343/280502Test |
| حقوق: | CC BY NC ND ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.B6D5EF4F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20511426 |
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