دورية أكاديمية
Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects.
| العنوان: | Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects. |
|---|---|
| المؤلفون: | Kraft, Walter K., Gilmartin, J H, Chappell, D L, Gheyas, F, Walker, B M, Nagalla, S, Naik, U P, Horrow, J C, Wrishko, R E, Zhang, S, Anderson, M S |
| المصدر: | Department of Pharmacology and Experimental Therapeutics Faculty Papers |
| بيانات النشر: | Jefferson Digital Commons |
| سنة النشر: | 2016 |
| المجموعة: | Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
| مصطلحات موضوعية: | Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences |
| الوصف: | The effect of the protease-activated receptor-1 (PAR-1) antagonist vorapaxar on human bleeding time is not known. This was a randomized, two-period, open-label trial in healthy men (n = 31) and women (n = 5). In period 1, subjects received 81 mg aspirin q.d. or a vorapaxar regimen achieving steady-state plasma concentrations equivalent to chronic 2.5 mg q.d. doses, for 7 days. In period 2, each group added 7 days of the therapy alternate to that of period 1 without washout. Bleeding time and platelet aggregation using arachidonic acid, ADP, and TRAP agonists were assessed. Bleeding time geometric mean ratio (90% CI) for vorapaxar/baseline was 1.01 (0.88-1.15), aspirin/baseline was 1.32 (1.15-1.51), vorapaxar + aspirin/vorapaxar was 1.47 (1.26-1.70), and vorapaxar + aspirin/aspirin was 1.12 (0.96-1.30). Unlike aspirin, vorapaxar did not prolong bleeding time compared with baseline. Bleeding time following administration of vorapaxar with aspirin was similar to that following aspirin alone. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://jdc.jefferson.edu/petfp/73Test; https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1073&context=petfpTest |
| الإتاحة: | https://jdc.jefferson.edu/petfp/73Test https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1073&context=petfpTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.B6C8C7BB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |