دورية أكاديمية
Anti-leukemic effects of all-trans retinoic acid in combination with Daratumumab in acute myeloid leukemia
| العنوان: | Anti-leukemic effects of all-trans retinoic acid in combination with Daratumumab in acute myeloid leukemia |
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| المؤلفون: | Buteyn, Nathaniel J, Fatehchand, Kavin, Santhanam, Ramasamy, Fang, Huiqing, Dettorre, Gino M, Gautam, Shalini, Harrington, Bonnie K, Henderson, Sally E, Merchand-Reyes, Giovanna, Mo, Xiaokui, Benson, Don M, Carson, William E, Vasu, Sumithira, Byrd, John C, Butchar, Jonathan P, Tridandapani, Susheela |
| المساهمون: | National Institutes of Health, NIH, Ohio State University Comprehensive Cancer Center, Ohio State University Comprehensive Cancer Center Leukemia Research Program Seed Award |
| المصدر: | International Immunology ; volume 30, issue 8, page 375-383 ; ISSN 0953-8178 1460-2377 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2018 |
| الوصف: | Acute myeloid leukemia (AML) remains a significant health problem, with poor outcomes despite chemotherapy and bone marrow transplants. Although one form of AML, acute promyelocytic leukemia (APL), is successfully treated with all-trans retinoic acid (ATRA), this drug is seemingly ineffective against all other forms of AML. Here, we show that ATRA up-regulates CD38 expression on AML blasts to sufficient levels that promote antibody-mediated fratricide following the addition of anti-CD38 daratumumab (DARA). The combination of ATRA plus DARA induced Fc-dependent conjugate formation and cytotoxicity among AML blasts in vitro. Combination treatment also led to reduction in tumor volume and resulted in increased overall survival in murine engraftment models of AML. These results suggest that, although ATRA does not induce differentiation of non-APL, it may be effective as a therapy in conjunction with DARA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/intimm/dxy040 |
| الإتاحة: | https://doi.org/10.1093/intimm/dxy040Test https://academic.oup.com/intimm/article-pdf/30/8/375/44799920/dxy040.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.B6AE752 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/intimm/dxy040 |
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