دورية أكاديمية
Oral administration of herbal oligonucleotide drug JGL-sRNA-h7 ameliorates hyperglycemia in db/db mice and beagle dogs.
| العنوان: | Oral administration of herbal oligonucleotide drug JGL-sRNA-h7 ameliorates hyperglycemia in db/db mice and beagle dogs. |
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| المؤلفون: | Tang, Kegong, Wang, Xiaona, Jiang, Zhenyu, Chen, Mingrui, Deng, Xingyu, Mei, Song, Ma, Yiming, Du, Xinyi, Guo, Shaoting, Lin, Yexuan, Dong, Yixin, Liu, Dengyuan, Xu, Longxin, Jiang, Chengyu |
| المصدر: | IUBMB Life ; ISSN:1521-6551 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | hyperglycemia, oligonucleotide drug, oral administration |
| الوصف: | Type 2 diabetes mellitus is a prevalent metabolic disease, posing a considerable threat to public health. Oligonucleotide drugs have proven to be a promising field of therapy for the diseases. In this study, we reported that a herbal small RNA (sRNA), JGL-sRNA-h7 (B34735529, F1439.L002444.A11), could exhibit potent hypoglycemic effects by targeting glucose-6-phosphatase. Oral administration of sphingosine (d18:1)-JGL-sRNA-h7 bencaosomes ameliorated hyperglycemia and diabetic kidney injury better than metformin in db/db mice. Furthermore, glucose tolerance was also improved in sphingosine (d18:1)-JGL-sRNA-h7 bencaosomes-treated beagle dogs. Our study indicates that JGL-sRNA-h7 could be a promising hypoglycemic oligonucleotide drug. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1002/iub.2859Test; https://pubmed.ncbi.nlm.nih.gov/38935610Test |
| DOI: | 10.1002/iub.2859 |
| الإتاحة: | https://doi.org/10.1002/iub.2859Test https://pubmed.ncbi.nlm.nih.gov/38935610Test |
| حقوق: | © 2024 International Union of Biochemistry and Molecular Biology. |
| رقم الانضمام: | edsbas.B696B259 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/iub.2859 |
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