دورية أكاديمية
'SYNTHESIS OF VARIOUS ANTHRAQUINONES DERIVATIVES AND ITS BIOLOGICAL EVALUATION AS NEUROPROTECTIVE AGENTS'
| العنوان: | 'SYNTHESIS OF VARIOUS ANTHRAQUINONES DERIVATIVES AND ITS BIOLOGICAL EVALUATION AS NEUROPROTECTIVE AGENTS' |
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| المؤلفون: | Chandrakant P Suryawanshi, Dr. R. D. Wagh |
| سنة النشر: | 2023 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Anthracene, Parkinson's Ailment, Oxotremorine, Tremor, Procyclidine |
| الوصف: | Parkinson’s ailment is especially outstanding from other situations based totally on the vital function of tremors. Oxotremorine-triggered oxidative pressure is a commonplace pathway in growing Parkinson’s signs like tremors, salivation, and temperature version. Subsequently, the Oxotremorine-precipitated tremor version changed used to assess Antiparkinsonian tablets. Distinct Anthraquinones derivatives compound 1 to16 have been formulated using appropriate schemes 1to 4 to investigate the Antiparkinsonian impact on Oxotremorine- brought on Parkinson’s symptoms in mice. Procyclidine, an anticholinergic, Antiparkinsonian drug was administered as a generic drug at a dose of 5 mg/kg p. o., 1hr prior to the administration of Oxotremorine (0.5 mg/kg) S.C. Numerous synthetic Anthraquinones compounds administered 200 mg/kg p. o. route of administration to reduce Parkinson’s symptoms. This look at indicates synthetic Anthraquinones compounds 1, 2, 6, eight, 12, and 14 show marked response to Parkinsonism symptoms compared to Procyclidine. From this research it is always worthy to synthesize various novel amino Anthraquinones compounds by considering Carboxamide linkage with various heterocyclic compounds as a neuroprotective agent helpful in PA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/communities/iajprTest; https://zenodo.org/record/7686984Test; https://doi.org/10.5281/zenodo.7686984Test; oai:zenodo.org:7686984 |
| DOI: | 10.5281/zenodo.7686984 |
| الإتاحة: | https://doi.org/10.5281/zenodo.7686984Test https://doi.org/10.5281/zenodo.7686983Test https://zenodo.org/record/7686984Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.B634BC05 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.7686984 |
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