دورية أكاديمية
Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infections in Intensive Care Units: A Multicentre Case-Control Study with a Competing-Risks Analysis: Risk factors for CRKP infections
| العنوان: | Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infections in Intensive Care Units: A Multicentre Case-Control Study with a Competing-Risks Analysis: Risk factors for CRKP infections |
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| المؤلفون: | arslan, ferhat, Akbulut, Ece, Senbayrak, Seniha, Ozgultekin, Asu, Aksaray, Sebehat, Cankar Dal, Hayriye, Emir, Hasan Oktay, Ankaralı, Handan, Mert, Ali, Vahaboglu, Haluk |
| المصدر: | Journal of Preventive Medicine and Hygiene; Vol. 64 No. 4 (2023): ; E405 ; 2421-4248 ; 1121-2233 ; 10.15167/2421-4248/jpmh2023.64.4 |
| بيانات النشر: | Department of Health Science - University of Genoa |
| سنة النشر: | 2024 |
| المجموعة: | Journal of Preventive Medicine and Hygiene (JPMH) |
| مصطلحات موضوعية: | Klebsiella pneumoniae, carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, intensive care units, risk factors, Prevention of Nosocomial infections |
| الوصف: | Aim: This study investigated the risk factors for the development of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in adult patients in intensive care units (ICUs). Methods: A multicentre case-control study was conducted in ICUs in three tertiary hospitals in Turkey. The cases were patients culture-confirmed CRKP and a condition associated with healthcare-associated infections. Two controls were randomly selected for each case from among all other patients with an ICU stay at least as long as that of the corresponding case patient. A proportional semiparametric subdistribution hazards regression model was used to assess risk factors for CRKP infection. ICU discharge and non-CRKP-related deaths were treated as competing risks. Results: A total of 120 patients, 44 cases, and 76 controls were included in the analysis. Of the controls, 32 were discharged from the ICU and 44 died without acquiring CRKP infection. Endotracheal intubation (hazard ratio [HR]: 1.96, 95% confidence interval [CI]: 1.00–3.868) and type 2 diabetes mellitus (HR: 1.57, 95% CI: 0.888–2.806) were associated with an increased risk of CRKP infection, whereas carbapenem exposure (HR: 0.47, 95% CI: 0.190–1.1175) and the presence of a nasogastric tube (HR: 0.49, 95% CI: 0.277–0.884) were associated with a decreased risk of CRKP infection. Conclusions: Enteral nutrition support via a nasogastric tube may be associated with a reduced risk of CRKP-resistant infections in ICU patients. This hypothesis should be tested with a well-designed study. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.jpmh.org/index.php/jpmh/article/view/2110/1126Test; https://www.jpmh.org/index.php/jpmh/article/view/2110Test |
| الإتاحة: | https://doi.org/10.15167/2421-4248/jpmh2023.64.4Test https://www.jpmh.org/index.php/jpmh/article/view/2110Test |
| حقوق: | Copyright (c) 2024 Journal of Preventive Medicine and Hygiene |
| رقم الانضمام: | edsbas.B5E5D734 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |