دورية أكاديمية
Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study
| العنوان: | Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study |
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| المؤلفون: | Zabel, M, Willems, R, Lubinski, A, Bauer, A, Brugada, J, Conen, D, Flevari, P, Hasenfuß, G, Svetlosak, M, Huikuri, HV, Malik, M, Pavlović, N, Schmidt, G, Sritharan, R, Schlögl, S, Szavits-Nossan, J, Traykov, V, Tuinenburg, AE, Willich, SN, Harden, M, Friede, T, Svendsen, JH, Sticherling, C, Merkely, B, Perge, P, Sallo, Z, Szeplaki, G, Szegedi, N, Nagy, KV, Lüthje, L, Haarmann, H, Bergau, L, Seegers, J, Munoz-Exposito, P, Tichelbäcker, T, Kirova, A, Hnatkova, K, Vos, MA, Reinhold, T, Vandenberk, B, Klinika, M, Rotkvić, L, Katsimardos, A, Katsaras, D, Hatala, R, Kuczejko, T, Hansen, J, Manola, Š, Vinter, O, Benko, I, Tuinenburg, A, Sprenkeler, D, Smoczynska, A, Meyer-Zürn, C, Eick, C, Arbelo, E, Kaliska, G, Martinek, J, Dommasch, M, Steger, A, Kääb, S, Sinner, MF, Rizas, KD, Hamm, W, Cygankiewicz, I, Ptaszyński, P, Kaczmarek, K, Poddebska, I, Iovev, S, Novotný, T, Kozak, M, Huikuri, H, Kenttä, T, Pelli, A, Kasprzak, JD, Qavoq, D, Brusich, S, Avdovic, E, Klasan, M, Galuszka, J, Taborsky, M, Velchev, V, Dissmann, R, Shalganov, T, Guzik, P, Krauze, T, Bimmel, D, Lieberz, C, Ludwigsburg, K, Stefanow, S, Rüb, N, Wolpert, C, Meier, LS, Behrens, S, Jurisic, Z, Braunschweig, F, Blaschke, F, Pieske, B, Bakotic, Z, Anic, A, Weiden, K, Schwinger, RHG, Platonov, P, Grönefeld, G, Klingenheben, T |
| المصدر: | 3447 ; 3437 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Implantable cardioverter-defibrillator, Mortality, Risk factors, Sudden cardiac death, EU-CERT-ICD Study Investigators, Cardiovascular System & Hematology, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences |
| الوصف: | Aims The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy. Methods and results We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. Primary endpoint was all-cause mortality. Clinical characteristics, medications, resting, and 12-lead Holter electrocardiograms (ECGs) were documented at enrolment baseline. Baseline and follow-up (FU) data from 2247 patients were analysable, 1516 patients before first ICD implantation (ICD group) and 731 patients without ICD serving as controls. Multivariable models and propensity scoring for adjustment were used to compare the two groups for mortality. During mean FU of 2.4 ± 1.1 years, 342 deaths occurred (6.3%/years annualized mortality, 5.6%/years in the ICD group vs. 9.2%/years in controls), favouring ICD treatment [unadjusted hazard ratio (HR) 0.682, 95% confidence interval (CI) 0.537–0.865, P = 0.0016]. Multivariable mortality predictors included age, left ventricular ejection fraction (LVEF), New York Heart Association class |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0195-668X |
| العلاقة: | European Heart Journal; http://hdl.handle.net/10044/1/79044Test |
| DOI: | 10.1093/eurheartj/ehaa226 |
| الإتاحة: | https://doi.org/10.1093/eurheartj/ehaa226Test http://hdl.handle.net/10044/1/79044Test |
| حقوق: | © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0Test/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| رقم الانضمام: | edsbas.B5B9D4F1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0195668X |
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| DOI: | 10.1093/eurheartj/ehaa226 |