دورية أكاديمية
Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension
| العنوان: | Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension |
|---|---|
| المؤلفون: | Ataga, Kenneth I., Moore, Charity G., Hillery, Cheryl A., Jones, Susan, Whinna, Herbert C., Strayhorn, Dell, Sohier, Cathy, Hinderliter, Alan, Parise, Leslie V., Orringer, Eugene P. |
| المساهمون: | School of Medicine, Department of Medicine, School of Medicine, Department of Pathology and Laboratory Medicine, UNC Medical Center, School of Medicine, Department of Biochemistry and Biophysics |
| المصدر: | Haematologica, 93(1) |
| سنة النشر: | 2008 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Hypertension artérielle pulmonaire, Respiratory disease, Hemopathy, Sickle cell anemia, Anémie à hématies falciformes, Hemoglobinopathy, Cellule endothéliale, Genetic disease, Cardiovascular disease, inflammation, Hemolytic anemia, Hematology, Endothelial cell, Pathologie de l'appareil respiratoire, Hématologie, Blood coagulation, pulmonary hypertension, endothelial activation, sickle cell disease, Coagulation sanguine, coagulation activation |
| الوصف: | BACKGROUND: Pulmonary hypertension (PHT) is common in sickle cell disease (SCD). The purpose of this study was to determine whether markers of coagulation activation and inflammation are associated with PHT in SCD. DESIGN AND METHODS: This cross-sectional study was performed using a cohort of patients followed at an adult Sickle Cell Clinic. Pulmonary artery systolic pressure was determined by Doppler echocardiography, and the diagnosis of PHT was defined using age, sex and body mass index-adjusted reference ranges. Clinical laboratory examinations, including hematologic studies and biochemical tests, as well as various measures of coagulation activation, endothelial activation and inflammation, were conducted on SCD subjects and on healthy, race-matched control subjects without SCD. RESULTS: Patients with SCD (n=76) had higher plasma levels of markers of coagulation (thrombin-antithrombin complex, prothrombin fragment F1+2, D-dimer) and endothelial (soluble vascular endothelial cell adhesion molecule, sVCAM) activation compared with control subjects (n=6). SCD patients with PHT (n=26) had significantly higher levels of sVCAM compared with those patients without PHT (n=50). Although PHT patients showed increased plasma measures of coagulation activation, the differences were not statistically significant when compared to those of patients without PHT. HbSS patients with PHT also had a trend towards higher levels of other inflammatory cytokines (interleukins 6, 8 and 10) than HbSS patients without PHT. There was a modest negative correlation between hemoglobin and plasma measures of coagulation and endothelial activation, and modest positive correlations between markers of hemolysis and plasma measures of coagulation and endothelial activation. CONCLUSIONS: SCD patients with PHT have higher levels of markers of endothelial activation and other inflammatory markers than patients without PHT. A trend towards an increased level of markers of coagulation activation was observed in SCD patients with PHT compared with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://doi.org/10.17615/73cj-cs83Test; https://cdr.lib.unc.edu/downloads/hd76s8022?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/hd76s8022Test |
| DOI: | 10.17615/73cj-cs83 |
| الإتاحة: | https://doi.org/10.17615/73cj-cs83Test https://cdr.lib.unc.edu/downloads/hd76s8022?file=thumbnailTest https://cdr.lib.unc.edu/downloads/hd76s8022Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.B571CA62 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/73cj-cs83 |
|---|