دورية أكاديمية
RECURRENT PREGNANCY LOSS IN WOMEN WITH HASHIMOTO'S THYROIDITIS WITH CONCURRENT NON-ENDOCRINE AUTOIMMUNE DISORDERS
| العنوان: | RECURRENT PREGNANCY LOSS IN WOMEN WITH HASHIMOTO'S THYROIDITIS WITH CONCURRENT NON-ENDOCRINE AUTOIMMUNE DISORDERS |
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| المؤلفون: | Cellini, Miriam, Santaguida, Maria Giulia, Stramazzo, Ilaria, Capriello, Silvia, Brusca, Nunzia, Antonelli, Alessandro, Fallahi, Poupak, Gargano, Lucilla, Centanni, Marco, Virili, Camilla |
| المساهمون: | Cellini, Miriam, Santaguida, Maria Giulia, Stramazzo, Ilaria, Capriello, Silvia, Brusca, Nunzia, Antonelli, Alessandro, Fallahi, Poupak, Gargano, Lucilla, Centanni, Marco, Virili, Camilla |
| سنة النشر: | 2020 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | recurrent pregnancy loss, miscarriage, Hashimoto's thyroiditis, hypothyroidism |
| الوصف: | BACKGROUND: An increased rate of recurrent miscarriage has been described in patients with autoimmune thyroid disease. However, there is a lack of studies that assess the rate of recurrent pregnancy loss (RPL) in patients with Hashimoto's thyroiditis (HT) isolated or with concurrent non-endocrine autoimmune disorders (NEAD). The objective of the study was to assess the rate of recurrent pregnancy loss in patients with HT isolated or accompanied with non-endocrine autoimmune diseases. METHODS: This is a retrospective observational cohort study with systematic review of the NEAD with concurrent HT in an outpatient Endocrinology Unit at a University Hospital. Among the 3480 consecutively examined women with HT, 87 patients met the criteria of RPL and represented the study group. Sixty-five of them had isolated HT and 22 women had HT+NEAD. RESULTS: The rate of RPL in women with HT was 2.1% versus 5.64% observed in women with HT+NEAD (OR=2.78, 95%CI=1.70-4.57; p<0.0001). Upon subdivision, this difference was still evident in euthyroid patients (p<0.0001), while it disappeared in hypothyroid women (p=0.21). RPL did not correlate with the autoantibody concentrations nor in women with isolated HT nor in those with HT+NEAD. The presence of antiphospholipid syndrome (APS) explained RPL in 3/22 (14%) patients with HT+NEAD, the remaining being related to different autoimmune disorders. Interestingly, even subtracting the patients with APS, RPL was more frequent in patients with poly-autoimmunity than in patients with isolated HT (p=0.0013). CONCLUSIONS: The co-presence of NEAD is correlated with a higher risk of RPL in women with HT. The association with APS may explain only a fraction of RPL rate in patients with polyautoimmunity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31910128; info:eu-repo/semantics/altIdentifier/wos/WOS:000524895400016; volume:30; issue:3; firstpage:457; lastpage:462; numberofpages:6; journal:THYROID; https://hdl.handle.net/11568/1027844Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85081945011 |
| DOI: | 10.1089/thy.2019.0456 |
| الإتاحة: | https://doi.org/10.1089/thy.2019.0456Test https://hdl.handle.net/11568/1027844Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B5530DF4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/thy.2019.0456 |
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