دورية أكاديمية
The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes
| العنوان: | The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes |
|---|---|
| المؤلفون: | Rickta Rani Das, Md. Atiar Rahman, Salahuddin Qader Al-Araby, Md. Shahidul Islam, Md. Mamunur Rashid, Nouf Abubakr Babteen, Afnan M. Alnajeebi, Hend Faisal H. Alharbi, Philippe Jeandet, Md. Khalid Juhani Rafi, Tanvir Ahmed Siddique, Md. Nazim Uddin, Zainul Amiruddin Zakaria |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | The purpose of this study was to look into the effects of green coconut mesocarp juice extract (CMJE) on diabetes-related problems in streptozotocin- (STZ-) induced type 2 diabetes, as well as the antioxidative functions of its natural compounds in regulating the associated genes and biochemical markers. CMJE’s antioxidative properties were evaluated by the standard antioxidant assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radical, nitric oxide, and ferrous ions along with the total phenolic and flavonoids content. The α-amylase inhibitory effect was measured by an established method. The antidiabetic effect of CMJE was assayed by fructose-fed STZ-induced diabetic models in albino rats. The obtained results were verified by bioinformatics-based network pharmacological tools: STITCH, STRING, GSEA, and Cytoscape plugin cytoHubba bioinformatics tools. The results showed that GC-MS-characterized compounds from CMJE displayed a very promising antioxidative potential. In an animal model study, CMJE significantly (P<0.05) decreased blood glucose, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, uric acid, and lipid levels and increased glucose tolerance as well as glucose homeostasis (HOMA-IR and HOMA-b scores). The animal’s body weights and relative organ weights were found to be partially restored. Tissue architectures of the pancreas and the kidney were remarkably improved by low doses of CMJE. Compound-protein interactions showed that thymine, catechol, and 5-hydroxymethylfurfural of CMJE interacted with 84 target proteins. Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease. The data demonstrate the highly prospective use of CMJE in the regulation of tubulointerstitial tissues of patients with diabetic nephropathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1942-0900 1942-0994 |
| العلاقة: | http://dx.doi.org/10.1155/2021/9711176Test; https://doaj.org/toc/1942-0900Test; https://doaj.org/toc/1942-0994Test; https://doaj.org/article/c0e07d87e9c44cb2a5db8b7bf4e94f6aTest |
| DOI: | 10.1155/2021/9711176 |
| الإتاحة: | https://doi.org/10.1155/2021/9711176Test https://doaj.org/article/c0e07d87e9c44cb2a5db8b7bf4e94f6aTest |
| رقم الانضمام: | edsbas.B53A9EBA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19420900 19420994 |
|---|---|
| DOI: | 10.1155/2021/9711176 |