دورية أكاديمية
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma
| العنوان: | Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma |
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| المؤلفون: | Michael J Nathenson, Constance M Barysauskas, Robert A Nathenson, William F Regine, Nader Hanna, Edward Sausville |
| المصدر: | World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-11 (2018) |
| بيانات النشر: | BMC |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Soft tissue sarcoma, Retroperitoneal, Leiomyosarcoma, Liposarcoma, Overall survival, Progression-free survival, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background Retroperitoneal soft tissue sarcomas (STS) include a number of histologies but are rare, with approximately 3000 cases in the USA per year. Retroperitoneal STS have a high incidence of local and distant recurrence. The purpose of this study was to review the University of Maryland Medical Center’s (UMMC) treatment experience of retroperitoneal STS, where the patient population served represents a diverse socioeconomic and ethnic catchment. Methods IRB approval was obtained. We constructed a de-identified database of patients diagnosed with retroperitoneal liposarcomas (LPS) or leiomyosarcomas (LMS) treated at UMMC between 2000 and 2013. A total of 49 patients (Pts) with retroperitoneal STS met our eligibility criteria. Kaplan-Meier plots were used to graphically portray progression-free survival (PFS) and overall survival (OS). The log-rank test was used to compare time-to-event distributions. Results The median OS for all patients (Pts) was 6.3 years, and the 2-year OS rate was 81%. The median PFS for all Pts was 1.8 years, and the 2-year PFS rate was 45%. There was no difference in OS and PFS among LMS and LPS patients; the median OS for LMS was 3.8 years vs. LPS 6.4 years (p = 0.33), and the median PFS for LMS was 1.2 years vs. LPS 2.5 years (p = 0.28). There was a significant difference between histology and race (p = 0.001). LPS were primarily Caucasian 86% vs. 14% black, whereas LMS were primarily black 52% vs. 33% Caucasian. OS was influenced by functional status, gender, American Joint Committee on Cancer (AJCC) stage, grade, histology, tumor size, and extent of resection. PFS was influenced by AJCC stage, grade, and extent of resection. Neither adjuvant chemotherapy (1 Pt) nor neoadjuvant/adjuvant radiation therapy (18 Pts) influenced OS or PFS. There was a non-significant difference that Pts who could undergo resection of local recurrence had improved 2-year OS, with 100% LMS and LPS compared to 2-year OS of 71% (LMS) and 78% (LPS) not undergoing resection of local recurrence. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1477-7819 |
| العلاقة: | http://link.springer.com/article/10.1186/s12957-018-1505-4Test; https://doaj.org/toc/1477-7819Test; https://doaj.org/article/681365d47a4e4af7b026e40b84610b3cTest |
| DOI: | 10.1186/s12957-018-1505-4 |
| الإتاحة: | https://doi.org/10.1186/s12957-018-1505-4Test https://doaj.org/article/681365d47a4e4af7b026e40b84610b3cTest |
| رقم الانضمام: | edsbas.B51B31AA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14777819 |
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| DOI: | 10.1186/s12957-018-1505-4 |