دورية أكاديمية
Agreement between real-time elastography and delayed enhancement magnetic resonance enterography on quantifying bowel wall fibrosis in Crohn's disease
| العنوان: | Agreement between real-time elastography and delayed enhancement magnetic resonance enterography on quantifying bowel wall fibrosis in Crohn's disease |
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| المؤلفون: | Mazza S., Conforti F. S., Forzenigo L. V., Piazza N., Berte R., Costantino A., Fraquelli M., Coletta M., Rimola J., Vecchi M., Caprioli F. |
| المساهمون: | S. Mazza, F.S. Conforti, L.V. Forzenigo, N. Piazza, R. Berte, A. Costantino, M. Fraquelli, M. Coletta, J. Rimola, M. Vecchi, F. Caprioli |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Crohn's disease, Fibrosi, Magnetic resonance imaging, Real-time elastography, Settore MED/12 - Gastroenterologia, Settore MED/36 - Diagnostica per Immagini e Radioterapia |
| الوصف: | Background: the assessment of fibrosis in Crohn's disease (CD) bowel lesions helps to guide therapeutic decisions. Real-time elastography (RTE) and delayed-enhancement magnetic resonance enterography (DE-MRE) have demonstrated good accuracy in quantifying CD-related ileal fibrosis as compared with histological examination. To date no study has compared DE-MRE and RTE. Aims: we aimed to evaluate the agreement between RTE and DE-MRE on quantifying CD-related ileal fibrosis. Methods: consecutive patients with ileal or ileocolonic CD underwent RTE and DE-MRE. Ileal fibrosis was quantified by calculating the strain ratio (SR) at RTE and the 70s-7 min percentage of enhancement gain (%EG) of both mucosa and submucosa at DE-MRE. A SR ≥2 was applied to define severe fibrosis. Clinically relevant outcomes occurring at follow-up were recorded. Results: 40 CD patients were enrolled. A significant linear correlation was observed between SR and submucosal %EG (r = 0.594, p < 0.001). Patients with severe fibrosis (SR ≥2) had significantly higher submucosal %EG values than patients with low/moderate fibrosis (median values 26.4% vs. 9.5%, p < 0.001). During a median 43.8-month follow-up relevant disease outcomes occurred more frequently in the severe-fibrosis group (75% vs. 36%, HR 5.4, 95% CI 1.2–24.6, p = 0.029). Conclusions: the study demonstrates an excellent agreement between RTE and DE-MRE in assessing ileal fibrosis in CD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34116973; info:eu-repo/semantics/altIdentifier/wos/WOS:000697954500064; firstpage:1; lastpage:7; numberofpages:7; journal:DIGESTIVE AND LIVER DISEASE; http://hdl.handle.net/2434/858897Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107664469 |
| DOI: | 10.1016/j.dld.2021.05.018 |
| الإتاحة: | https://doi.org/10.1016/j.dld.2021.05.018Test http://hdl.handle.net/2434/858897Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.B500FFDC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.dld.2021.05.018 |
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