دورية أكاديمية
The Role of Uncoupling Protein 3 in Human Physiology
| العنوان: | The Role of Uncoupling Protein 3 in Human Physiology |
|---|---|
| المؤلفون: | Garvey, W. Timothy |
| المصدر: | MUSC Faculty Journal Articles |
| بيانات النشر: | MEDICA |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | obesity, mitochondria, mitochondrial proteins, uncoupling agents, carrier proteins, electron transport, ion channels, biological models, oxidative phosphorylation, skeletal muscle, mice, fatty acids, animal models |
| الوصف: | Obesity is simply understood as an imbalance between energy intake and expenditure in favor of weight accretion. However, the human biological interface between food consumption and energy dissipation results in broad individual differences in eating behavior, physical activity, and efficiency of fuel storage and metabolism. In particular, the basal metabolic rate, which accounts for the greatest portion of overall energy expenditure, can vary almost twofold among individuals. Classically, three major biochemical systems are believed to contribute to basal thermogenesis: futile cycles, Na+/K+ATPase activity, and mitochondrial proton leak. The latter is the most important quantitative contributor and can explain up to 50% of the basal metabolic rate (1). The molecular basis of mitochondrial proton leak is unclear, despite its importance in the understanding of energy balance and its potential as a therapeutic target for obesity treatment. The article by Hesselink and colleagues in this issue of the JCI (2) addresses whether uncoupling protein 3 contributes to mitochondrial proton leak in human skeletal muscle. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://medica-musc.researchcommons.org/facarticles/24Test; https://medica-musc.researchcommons.org/cgi/viewcontent.cgi?article=1023&context=facarticlesTest |
| الإتاحة: | https://medica-musc.researchcommons.org/facarticles/24Test https://medica-musc.researchcommons.org/cgi/viewcontent.cgi?article=1023&context=facarticlesTest |
| رقم الانضمام: | edsbas.B4ED844 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |