التفاصيل البيبلوغرافية
| العنوان: |
Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants |
| المؤلفون: |
Belik, Milja, Jalkanen, Pinja, Lundberg, Rickard, Reinholm, Arttu, Laine, Larissa, Väisänen, Elina, Skön, Marika, Tahtinen, Paula A., Ivaska, Lauri, Pakkanen, Sari H., Häkkinen, Hanni K., Ortamo, Eeva, Pasternack, Arja, Ritvos, Mikael A., Naves, Rauno A., Miettinen, Simo, Sironen, Tarja, Vapalahti, Olli, Ritvos, Olli, Österlund, Pamela, Kantele, Anu, Lempainen, Johanna, Kakkola, Laura, Kolehmainen, Pekka, Julkunen, Ilkka |
| المساهمون: |
University of Helsinki, Infektiosairauksien yksikkö, Helsinki University Hospital Area, Medicum, Department of Physiology, Faculty of Medicine, Department of Virology, HUSLAB, Helsinki One Health (HOH), Viral Zoonosis Research Unit, Emerging Infections Research Group, Veterinary Biosciences, Veterinary Microbiology and Epidemiology, Growth factor physiology, Department of Medicine |
| بيانات النشر: |
Nature Publishing Group |
| سنة النشر: |
2022 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
IMMUNOGENICITY, MULTICENTER, BNT162B2, 3121 General medicine, internal medicine and other clinical medicine |
| الوصف: |
Vaccination shows efficacy in protecting from COVID-19, but regime and dosing optimization is still ongoing. Here the authors show that BNT162b2, mRNA-1273, or their combination with ChAdOx1 induces similar antibody responses, and those receiving three doses of BNT162b2 induce neutralizing antibodies against the Omicron variant. Two COVID-19 mRNA (of BNT162b2, mRNA-1273) and two adenovirus vector vaccines (ChAdOx1 and Janssen) are licensed in Europe, but optimization of regime and dosing is still ongoing. Here we show in health care workers (n = 328) that two doses of BNT162b2, mRNA-1273, or a combination of ChAdOx1 adenovirus vector and mRNA vaccines administrated with a long 12-week dose interval induce equally high levels of anti-SARS-CoV-2 spike antibodies and neutralizing antibodies against D614 and Delta variant. By contrast, two doses of BNT162b2 with a short 3-week interval induce 2-3-fold lower titers of neutralizing antibodies than those from the 12-week interval, yet a third BNT162b2 or mRNA-1273 booster dose increases the antibody levels 4-fold compared to the levels after the second dose, as well as induces neutralizing antibody against Omicron BA.1 variant. Our data thus indicates that a third COVID-19 mRNA vaccine may induce cross-protective neutralizing antibodies against multiple variants. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
We thank Soili Jussila, Anne Suominen, Anne-Mari Pieniniemi, and Outi Debnam for technical assistance. This study was supported by the Academy of Finland (grant number 337530 to I.J., 336439 and 335527 to A.K., and 339512 to L.K.), Jane and Aatos Erkko Foundation (grant numbers 3067-84b53 and 5360-cc2fc to I.J., and 5359-89ef7 to O.V.), the Finnish Medical Foundation (to A.K.), the Sigrid Juselius Foundation (to I.J. and L.K.), Juho Vainio Foundation (to O.V.), and HUH Funds (TYH2021343 to O.V.).; Belik , M , Jalkanen , P , Lundberg , R , Reinholm , A , Laine , L , Väisänen , E , Skön , M , Tahtinen , P A , Ivaska , L , Pakkanen , S H , Häkkinen , H K , Ortamo , E , Pasternack , A , Ritvos , M A , Naves , R A , Miettinen , S , Sironen , T , Vapalahti , O , Ritvos , O , Österlund , P , Kantele , A , Lempainen , J , Kakkola , L , Kolehmainen , P & Julkunen , I 2022 , ' Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants ' , Nature Communications , vol. 13 , no. 1 , 2476 . https://doi.org/10.1038/s41467-022-30162-5Test; ORCID: /0000-0002-2344-2755/work/113986535; ORCID: /0000-0003-2270-6824/work/113986545; ORCID: /0000-0003-4522-5337/work/113987458; ORCID: /0000-0002-6088-4245/work/155655390; ORCID: /0009-0002-1107-522X/work/156153294; http://hdl.handle.net/10138/344286Test; b5990a41-ebea-4d23-9e51-fbe2542ffb62; 000791508600018 |
| الإتاحة: |
http://hdl.handle.net/10138/344286Test |
| حقوق: |
cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.B4A015C7 |
| قاعدة البيانات: |
BASE |
