التفاصيل البيبلوغرافية
| العنوان: |
Abstract 279: Resolvin D2 and Maresin 1 Modulate Vascular Inflammation, Cell Migration Aad Macrophage Polarization in a Mouse Model of Arterial Injury |
| المؤلفون: |
Akagi, Daisuke, Chen, Mian, Toy, Robert, Mottola, Giorgio, Chatterjee, Anuran, Conte, Michael S |
| المصدر: |
Arteriosclerosis, Thrombosis, and Vascular Biology ; volume 35, issue suppl_1 ; ISSN 1079-5642 1524-4636 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2015 |
| الوصف: |
Introduction: Vascular injury induces a potent inflammatory response that influences vessel remodeling and patency, limitinglimits the long-term benefits of cardiovascular interventions such as angioplasty. Specialized pro-resolving lipid mediators (SPMs) derived from omega-3 polyunsaturated fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) orchestrate resolution in diverse settings of acute inflammation. We hypothesized that systemic administration of DHA-derived SPMs (resolvin D2 [RvD2] and maresin 1 [MaR1]) would influence vessel remodelinginflammation and remodeling in a mouse model of arterial neointima formation (carotid ligation). Methods and Results: In-vitro, SPM treatment inhibited mouse aortic smooth muscle cell (SMC) migration (IC50@1 nM) to a PDGF gradient and reduced tumor necrosis factor-α stimulated p65 translocation, superoxide production and pro-inflammatory gene expression (MCP-1). In vivo, adult FVB mice underwent unilateral carotid arteryi ligation with administration of RvD2, MaR1, or vehicle (100ng by intraperitoneal injection at 0, 1, 3, 5 and 7 days post ligation). In ligated carotid arteries at 4 days, SPM treatment was associated with reduced cell proliferation, neutrophil and macrophage recruitment, and increased polarization of M2 macrophages in the arterial wall (M2 macrophage proportion; RvD2 62%, MaR1 51% and control 43%). Neointimal hyperplasia (at 14 days) was notably attenuated in RvD2 (62%) and MaR1 (67%) treated mice, respectively. Proliferating cells at 14 days are mainly SMCs. Conclusion: Modulation of resolution pathways may offer new opportunities to regulate the vascular injury response and promote vascular homeostasis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1161/atvb.35.suppl_1.279 |
| الإتاحة: |
https://doi.org/10.1161/atvb.35.suppl_1.279Test |
| رقم الانضمام: |
edsbas.B4826D4 |
| قاعدة البيانات: |
BASE |
