دورية أكاديمية
Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice
| العنوان: | Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice |
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| المؤلفون: | Rives, Clémence, Martin, Céline, Marie Pauline, Evariste, Lauris, Polizzi, Arnaud, Huillet, Marine, Lasserre, Frédéric, Alquier‐bacquie, Valérie, Perrier, Prunelle, Gomez, Jelskey, Lippi, Yannick, Naylies, Claire, Levade, Thierry, Sabourdy, Frédérique, Remignon, Hervé, Fafournoux, Pierre, Chassaing, Benoit, Loiseau, Nicolas, Guillou, Hervé, Ellero‐simatos, Sandrine, Gamet‐payrastre, Laurence, Fougerat, Anne |
| المساهمون: | Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | ISSN: 1613-4125. |
| بيانات النشر: | HAL CCSD Wiley-VCH Verlag |
| سنة النشر: | 2023 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Scope: Non-alcoholic fatty liver disease (NAFLD) is a sexually dimorphic disease influenced by dietary factors. Here, the metabolic and hepatic effects of dietary amino acid (AA) source is assessed in Western diet (WD)-induced NAFLD in male and female mice. Methods and results: The AA source is either casein or a free AA mixture mimicking the composition of casein. As expected, males fed a casein-based WD display glucose intolerance, fasting hyperglycemia, and insulin-resistance and develop NAFLD associated with changes in hepatic gene expression and microbiota dysbiosis. In contrast, males fed the AA-based WD show no steatosis, a similar gene expression profile as males fed a control diet, and a distinct microbiota composition compared to males fed a casein-based WD. Females are protected against WD-induced liver damage, hepatic gene expression, and gut microbiota changes regardless of the AA source. Conclusions: Free dietary AA intake prevents the unhealthy metabolic outcomes of a WD preferentially in male mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04287354; https://hal.inrae.fr/hal-04287354Test; https://hal.inrae.fr/hal-04287354/documentTest; https://hal.inrae.fr/hal-04287354/file/Molecular%20Nutrition%20Food%20Res%20-%202023%20-%20Rives%20-%20Dietary%20Amino%20Acid%20Source%20Elicits%20Sex%E2%80%90Specific%20Metabolic%20Response%20to.pdfTest; WOS: 001093467400001 |
| DOI: | 10.1002/mnfr.202300491 |
| الإتاحة: | https://doi.org/10.1002/mnfr.202300491Test https://hal.inrae.fr/hal-04287354Test https://hal.inrae.fr/hal-04287354/documentTest https://hal.inrae.fr/hal-04287354/file/Molecular%20Nutrition%20Food%20Res%20-%202023%20-%20Rives%20-%20Dietary%20Amino%20Acid%20Source%20Elicits%20Sex%E2%80%90Specific%20Metabolic%20Response%20to.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B4554085 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mnfr.202300491 |
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