رسالة جامعية
Central auditory deficits in genetic forms of deafness : example of Cdhr23 and Pcdh15 genes ; Déficits centraux auditifs dans les formes génétiques de surdité : l'exemple des gènes Cdhr23 et Pcdh15
| العنوان: | Central auditory deficits in genetic forms of deafness : example of Cdhr23 and Pcdh15 genes ; Déficits centraux auditifs dans les formes génétiques de surdité : l'exemple des gènes Cdhr23 et Pcdh15 |
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| المؤلفون: | Postal, Olivier |
| المساهمون: | Plasticité des Circuits auditifs centraux - Plasticity of central auditory circuits (PCAC), Institut de l'Audition Paris (IDA), Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Sorbonne Université, Boris Gourévitch, Nicolas Michalski |
| المصدر: | https://theses.hal.science/tel-04213556Test ; Neurobiologie. Sorbonne Université, 2022. Français. ⟨NNT : 2022SORUS324⟩. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Central auditory deficits, Cadherin 23, Protocadherin 15, Parvalbumin interneurons, Auditory cortex, Hyperexcitability, Déficits auditifs centraux, Cadhérine 23, Protocadhérine, Interneurones à parvalbumine, Cortex auditif, Hyperexcitabilité, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology |
| الوصف: | Over the past three decades, the study of hereditary forms of deafness has provided considerable insight into the molecular mechanisms of hearing, particularly those involved in the development and/or physiology of the auditory sensory organ, the cochlea. In contrast, the genetic approach has provided little information about the central auditory system although many people have central auditory dysfunctions. Central auditory deficits are poorly understood and can, in some cases, go unnoticed. This is likely as a result of cochlear damage depriving the brain of all or part of the acoustic information it would normally receive. To identify genetic forms of deafness that result in both peripheral and central hearing deficits, the Michalski research group uses the susceptibility of mice to audiogenic seizures, epileptic seizures triggered in response to loud sound, which are a manifestation of central deficits. Several strains of mice carrying mutations in deafness genes show susceptibility to audiogenic seizures in the bi-allelic state (if the deafness is not complete) or in the mono-allelic state. Through this strategy, two such genes, Cdhr23 and Pcdh15, have been identified to be involved in the establishment of cortical neurons expressing parvalbumin (PV) which serve as the primary cortical inhibitory neurons in the auditory cortex. The aim of my thesis was a) to develop tools to easily identify the presence of central auditory deficits in genetic models of deafness in mice and b) to further investigate the roles of cdhr23 and pcdh15 in the central auditory system through conditional inactivation of Cdhr23 and Pcdh15 in the mouse brain. First, I developed a non-invasive method to measure auditory cortical evoked potentials in mice and demonstrated that mice respond to certain aversive acoustic features differently to humans for which a large network of neurons (even outside the auditory system) is activated. These results will allow to study more precisely the central deficits associated with hearing ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | French |
| العلاقة: | NNT: 2022SORUS324; tel-04213556; https://theses.hal.science/tel-04213556Test; https://theses.hal.science/tel-04213556/documentTest; https://theses.hal.science/tel-04213556/file/POSTAL_Olivier_these_2022.pdfTest |
| الإتاحة: | https://theses.hal.science/tel-04213556Test https://theses.hal.science/tel-04213556/documentTest https://theses.hal.science/tel-04213556/file/POSTAL_Olivier_these_2022.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B4394FDF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |