التفاصيل البيبلوغرافية
| العنوان: |
The role of albumin–bilirubin grade in determining the outcomes of patients with very early-stage hepatocellular carcinoma |
| المؤلفون: |
Chang, Chung-Yu, Wei, Cheng-Yi, Chen, Ping-Hsien, Hou, Ming-Chih, Chao, Yee, Chau, Gar-Yang, Lee, Rheun-Chuan, Huang, Yi-Hsiang, Su, Yu-Hui, Wu, Jaw-Ching, Su, Chien-Wei |
| المصدر: |
Journal of the Chinese Medical Association ; volume 84, issue 2, page 136-143 ; ISSN 1726-4901 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2021 |
| الوصف: |
Background: Patients with hepatocellular carcinoma (HCC) and with a single tumor <2 cm in size are classified as having Barcelona Clinic Liver Cancer (BCLC) stage 0 HCC. We aimed to investigate the role of the albumin–bilirubin (ALBI) grade in predicting outcomes in patients with BCLC stage 0 HCC. Methods: We retrospectively enrolled patients with BCLC stage 0 HCC in Taipei Veterans General Hospital from 2007 to 2015. Prognostic factors were analyzed using a Cox proportional hazards model and propensity score matching (PSM) analysis. Results: There were 420 patients enrolled, including 207 with ALBI grade 1, and 213 with ALBI grade 2 or 3. After a median follow-up of 60.0 months (interquartile range, 37.2–84.6 months), 179 patients died. The cumulative 5-year overall survival (OS) rates were 80.6% in patients with ALBI grade 1 and 53.7% in those with ALBI grade 2 or 3, respectively ( p < 0.001). Multivariate analysis showed that age >65 years, negative hepatitis B surface in serum, creatinine >1.0 mg/dL, platelet count ≤10 5 /mm 3 , tumor size >1.5 cm, nonsurgical resection (SR) therapy, and higher ALBI grade were independent risk factors related to poor OS. Patients who underwent SR had a better OS and recurrence-free survival than those who received radiofrequency ablation, which was confirmed by a multivariate analysis and PSM analysis. Conclusion: The ALBI grade can determine OS for patients with BCLC stage 0 HCC. SR can also provide a better outcome than nonsurgical treatment. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/jcma.0000000000000482 |
| DOI: |
10.1097/JCMA.0000000000000482 |
| الإتاحة: |
https://doi.org/10.1097/jcma.0000000000000482Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.B41BB30F |
| قاعدة البيانات: |
BASE |
