دورية أكاديمية
Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix
| العنوان: | Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix |
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| المؤلفون: | Parodi, A, Haddix, SG, Taghipour, N, Scaria, S, Taraballi, F, Cevenini, A, Yazdi, IK, Corbo, C, Palomba, R, Khaled, SZ, Brown, BS, Martinez, JO, Isenhart, L, Tasciotti, E |
| المساهمون: | Parodi, A, Haddix, S, Taghipour, N, Scaria, S, Taraballi, F, Cevenini, A, Yazdi, I, Corbo, C, Palomba, R, Khaled, S, Brown, B, Martinez, J, Isenhart, L, Tasciotti, E |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2014 |
| المجموعة: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| مصطلحات موضوعية: | siRNA, drug delivery |
| الوصف: | Tumor extracellular matrix (ECM) represents a major obstacle to the diffusion of therapeutics and drug delivery systems in cancer parenchyma. This biological barrier limits the efficacy of promising therapeutic approaches including the delivery of siRNA or agents intended for thermoablation. After extravasation due to the enhanced penetration and retention effect of tumor vasculature, typical nanotherapeutics are unable to reach the nonvascularized and anoxic regions deep within cancer parenchyma. Here, we developed a simple method to provide mesoporous silica nanoparticles (MSN) with a proteolytic surface. To this extent, we chose to conjugate MSN to Bromelain (Br-MSN), a crude enzymatic complex, purified from pineapple stems, that belongs to the peptidase papain family. This surface modification increased particle uptake in endothelial, macrophage, and cancer cell lines with minimal impact on cellular viability. Most importantly Br-MSN showed an increased ability to digest and diffuse in tumor ECM in vitro and in vivo |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25119793; info:eu-repo/semantics/altIdentifier/wos/WOS:000343952600021; volume:8; issue:10; firstpage:9874; lastpage:9883; numberofpages:10; journal:ACS NANO; http://hdl.handle.net/10281/217914Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84908433122 |
| DOI: | 10.1021/nn502807n |
| الإتاحة: | https://doi.org/10.1021/nn502807nTest http://hdl.handle.net/10281/217914Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.B402EC2A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/nn502807n |
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