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Shedding Light on Targeting Chronic Myeloid Leukemia Stem Cells

التفاصيل البيبلوغرافية
العنوان: Shedding Light on Targeting Chronic Myeloid Leukemia Stem Cells
المؤلفون: Mohammad Houshmand, Alireza Kazemi, Ali Anjam Najmedini, Muhammad Shahzad Ali, Valentina Gaidano, Alessandro Cignetti, Carmen Fava, Daniela Cilloni, Giuseppe Saglio, Paola Circosta
المصدر: Journal of Clinical Medicine, Vol 10, Iss 5805, p 5805 (2021)
بيانات النشر: MDPI AG
سنة النشر: 2021
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: chronic myeloid leukemia, leukemia stem cells, bone marrow microenvironment, treatment free remission, Medicine
الوصف: Chronic myeloid leukemia stem cells (CML LSCs) are a rare and quiescent population that are resistant to tyrosine kinase inhibitors (TKI). When TKI therapy is discontinued in CML patients in deep, sustained and apparently stable molecular remission, these cells in approximately half of the cases restart to grow, resuming the leukemic process. The elimination of these TKI resistant leukemic stem cells is therefore an essential step in increasing the percentage of those patients who can reach a successful long-term treatment free remission (TFR). The understanding of the biology of the LSCs and the identification of the differences, phenotypic and/or metabolic, that could eventually allow them to be distinguished from the normal hematopoietic stem cells (HSCs) are therefore important steps in designing strategies to target LSCs in a rather selective way, sparing the normal counterparts.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2077-0383
العلاقة: https://www.mdpi.com/2077-0383/10/24/5805Test; https://doaj.org/toc/2077-0383Test; https://doaj.org/article/0815e0350a3d40169f4ed9edd15f0b46Test
DOI: 10.3390/jcm10245805
الإتاحة: https://doi.org/10.3390/jcm10245805Test
https://doaj.org/article/0815e0350a3d40169f4ed9edd15f0b46Test
رقم الانضمام: edsbas.B3F09D59
قاعدة البيانات: BASE
الوصف
تدمد:20770383
DOI:10.3390/jcm10245805