دورية أكاديمية
Chronic Venous Disease during Pregnancy Causes a Systematic Increase in Maternal and Fetal Proinflammatory Markers
| العنوان: | Chronic Venous Disease during Pregnancy Causes a Systematic Increase in Maternal and Fetal Proinflammatory Markers |
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| المؤلفون: | Ortega, Miguel A., Gómez Lahoz, Ana M., Sanchez Trujillo, Lara, Fraile Martínez, Oscar, García Montero, Cielo, Guijarro, Luis G., Bravo Arribas, Coral, León Luis, Juan Antonio, Saz, Jose V., Bujan, Julia, García Honduvilla, Natalio, Monserrat, Jorge, Álvarez Mon, Melchor |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 618.2, Pregnancy-induced CVD, Chronic venous disease, Proinflammatory cytokines, Hypertensive vascular disorder, MeSH, Medicina, Ginecología y obstetricia, 32 Ciencias Médicas, 3201.08 Ginecología |
| الوصف: | Chronic venous disease (CVD) is a common vascular disorder characterized by increased venous hypertension and insufficient venous return from the lower limbs. Pregnancy is a high-risk situation for developing CVD. Approximately a third of the women will develop this condition during pregnancy, and similarly to arterial hypertensive disorders, previous evidence has described a plethora of alterations in placental structure and function in women with pregnancy-induced CVD. It is widely known that arterial-induced placenta dysfunction is accompanied by an important immune system alteration along with increased inflammatory markers, which may provide detrimental consequences for the women and their offspring. However, to our knowledge, there are still no data collected regarding cytokine profiling in women with pregnancy-induced CVD. Thus, the aim of the present work was to examine cytokine signatures in the serum of pregnant women (PW) with CVD and their newborns (NB). This study was conducted through a multiplex technique in 62 PW with pregnancy-induced CVD in comparison to 52 PW without CVD (HC) as well as their NB. Our results show significant alterations in a broad spectrum of inflammatory cytokines (IL-6, IL-12, TNF-α, IL-10, IL-13, IL-2, IL-7, IFN-γ, IL-4, IL-5, IL-21, IL-23, GM-CSF, chemokines (fractalkine), MIP-3α, and MIP-1β). Overall, we demonstrate that pregnancy-induced CVD is associated with a proinflammatory environment, therefore highlighting the potentially alarming consequences of this condition for maternal and fetal wellbeing. ; Depto. de Salud Pública y Materno - Infantil ; Fac. de Medicina ; TRUE ; Unión Europea ; Comunidad de Madrid ; Instituto de Salud Carlos III ; Halekulani S.L ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | FEDER; B2017/BMD-3804 MITIC-CM; Subvención nº Estatal de I+D+I 2020-2027 (FIS-PI21/01244); https://doi.org/10.3390/ijms23168976Test; https://www.mdpi.com/journal/ijmsTest; https://hdl.handle.net/20.500.14352/72230Test |
| DOI: | 10.3390/ijms23168976 |
| الإتاحة: | https://doi.org/20.500.14352/72230Test https://doi.org/10.3390/ijms23168976Test https://hdl.handle.net/20.500.14352/72230Test https://www.mdpi.com/journal/ijmsTest |
| حقوق: | Atribución 3.0 España ; open access ; https://creativecommons.org/licenses/by/3.0/esTest/ |
| رقم الانضمام: | edsbas.B3761395 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms23168976 |