التفاصيل البيبلوغرافية
| العنوان: |
The yield of long-term electrocardiographic recordings in refractory focal epilepsy |
| المؤلفون: |
Lende, Marije van der, Arends, JBAM Johan, Lamberts, Robert J, Tan, HL Hanno, Lange, Frederik J de, Sander, Josemir W, Aerts, Arnaud J, Swart, Henk P, Thijs, Roland D |
| المصدر: |
ISSN:0013-9580. |
| بيانات النشر: |
Wiley-Blackwell |
| سنة النشر: |
2019 |
| المجموعة: |
Eindhoven University of Technology (TU/e): Research Portal |
| الوصف: |
OBJECTIVE: To determine the incidence of clinically relevant arrhythmias in refractory focal epilepsy and to assess the potential of postictal arrhythmias as risk markers for sudden unexpected death in epilepsy (SUDEP). METHODS: We recruited people with refractory focal epilepsy without signs of ictal asystole and who had at least one focal seizure per month and implanted a loop recorder with 2-year follow-up. The devices automatically record arrhythmias. Subjects and caregivers were instructed to make additional peri-ictal recordings. Clinically relevant arrhythmias were defined as asystole ≥ 6 seconds; atrial fibrillation < 55 beats per minute (bpm), or > 200 bpm and duration > 30 seconds; persistent sinus bradycardia < 40 bpm while awake; and second- or third-degree atrioventricular block and ventricular tachycardia/fibrillation. We performed 12-lead electrocardiography (ECG) and tilt table testing to identify non-seizure-related causes of asystole. RESULTS: We included 49 people and accumulated 1060 months of monitoring. A total of 16 474 seizures were reported, of which 4679 were captured on ECG. No clinically relevant arrhythmias were identified. Three people had a total of 18 short-lasting (<6 seconds) periods of asystole, resulting in an incidence of 2.91 events per 1000 patient-months. None of these coincided with a reported seizure; one was explained by micturition syncope. Other non-clinically relevant arrhythmias included paroxysmal atrial fibrillation (n = 2), supraventricular tachycardia (n = 1), and sinus tachycardia with a right bundle branch block configuration (n = 1). SIGNIFICANCE: We found no clinically relevant arrhythmias in people with refractory focal epilepsy during long-term follow-up. The absence of postictal arrhythmias does not support the use of loop recorders in people at high SUDEP risk. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://repository.tue.nl/915697Test |
| الإتاحة: |
http://repository.tue.nl/915697Test |
| حقوق: |
Copyright (c) Lende, Marije van der ; Copyright (c) Arends, JBAM Johan ; Copyright (c) Lamberts, Robert J ; Copyright (c) Tan, HL Hanno ; Copyright (c) Lange, Frederik J de ; Copyright (c) Sander, Josemir W ; Copyright (c) Aerts, Arnaud J ; Copyright (c) Swart, Henk P ; Copyright (c) Thijs, Roland D |
| رقم الانضمام: |
edsbas.B36F6EE |
| قاعدة البيانات: |
BASE |
