دورية أكاديمية
Active Flavonoids from Colubrina greggii var. greggii S. Watson against Clinical Isolates of Candida spp.
| العنوان: | Active Flavonoids from Colubrina greggii var. greggii S. Watson against Clinical Isolates of Candida spp. |
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| المؤلفون: | Elda M. Melchor-Martínez, Juan F. Tamez-Fernández, Gloria María González-González, David A. Silva-Mares, Noemí Waksman-Minsky, Luis Alejandro Pérez-López, Verónica M. Rivas-Galindo |
| المصدر: | Molecules, Vol 26, Iss 5760, p 5760 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | antifungal activity, candida spp, colubrina greggii var. greggii, bioassay-guided fractionation, Organic chemistry, QD241-441 |
| الوصف: | Candida albicans is the most commonly implicated agent in invasive human fungal infections. The disease could be presented as minimal symptomatic candidemia or can be fulminant sepsis. Candidemia is associated with a high rate of mortality and high healthcare and hospitalization costs. The surveillance programs have reported the distribution of other Candida species reflecting the trends and antifungal susceptibilities. Previous studies have demonstrated that C. glabrata more frequently presents fluconazole-resistant strains. Extracts from Mexican plants have been reported with activity against pulmonary mycosis, among them Colubrina greggii . In the present study, extracts from the aerial parts (leaves, flowers, and fruits) of this plant were evaluated against clinical isolates of several species of Candida ( C. albicans , C. glabrata , C. parapsilosis , C. krusei , and C. tropicalis ) by the broth microdilution assay. Through bioassay-guided fractionation, three antifungal glycosylated flavonoids were isolated and characterized. The isolated compounds showed antifungal activity only against C. glabrata resistant to fluconazole, and were non-toxic toward brine shrimp lethality bioassay and in vitro Vero cell line assay. The ethyl acetate and butanol extracts, as well as the fractions containing the mixture of flavonoids, were more active against Candida spp. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1420-3049 |
| العلاقة: | https://www.mdpi.com/1420-3049/26/19/5760Test; https://doaj.org/toc/1420-3049Test; https://doaj.org/article/de0576d115a24e3193d350a32d0022c6Test |
| DOI: | 10.3390/molecules26195760 |
| الإتاحة: | https://doi.org/10.3390/molecules26195760Test https://doaj.org/article/de0576d115a24e3193d350a32d0022c6Test |
| رقم الانضمام: | edsbas.B331BEDD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14203049 |
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| DOI: | 10.3390/molecules26195760 |