التفاصيل البيبلوغرافية
| العنوان: |
Graft-vs-Host Disease After Liver Transplantation: A Diagnostic and Management Challenge |
| المؤلفون: |
Chin, Jerry Yung-Lun, Gong, Jiayi, Gane, Edward |
| المصدر: |
ACG Case Reports Journal ; volume 7, issue 12, page e00499 ; ISSN 2326-3253 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2020 |
| الوصف: |
A 65-year-old White man underwent deceased donor liver transplant for decompensated liver cirrhosis secondary to alpha-1-antitrypsin deficiency. He developed diarrhea and diffuse maculopapular rash 2 months post-transplant. Skin biopsy revealed necroinflammatory changes related to the superficial dermis. Pancytopenia ensued, complicated by neutropenic sepsis. Chimerism studies confirmed the presence of donor T-lymphocyte macrochimerism (63%). The patient was diagnosed with graft-vs-host disease. After extensive multidisciplinary collaboration, basiliximab was initiated. This resulted in complete symptom resolution and a gradual reduction in T-lymphocyte macrochimerism (12%). The patient was later transitioned to oral ruxolitinib and currently remains in stable condition 16 months after being diagnosed with graft-vs-host disease. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.14309/crj.0000000000000499 |
| الإتاحة: |
https://doi.org/10.14309/crj.0000000000000499Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.B32E7D9D |
| قاعدة البيانات: |
BASE |
