دورية أكاديمية
Smoking and Risk of Prostate Cancer and Prostate Cancer Death : A Pooled Study
| العنوان: | Smoking and Risk of Prostate Cancer and Prostate Cancer Death : A Pooled Study |
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| المؤلفون: | Jochems, Sylvia H. J., Fritz, Josef, Häggström, Christel, Jarvholm, Bengt, Stattin, Pär, Stocks, Tanja |
| بيانات النشر: | Uppsala universitet, Endokrinkirurgi Uppsala universitet, Urologkirurgi Lund Univ, Dept Clin Sci Lund, Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, SE-22185 Lund, Sweden. Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria. Lund Univ, Dept Clin Sci Lund, Lund, Sweden.;Umeå Univ, Northern Register Ctr, Dept Publ Hlth & Clin Med, Umeå, Sweden. Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden. Lund Univ, Dept Clin Sci Lund, Lund, Sweden. |
| سنة النشر: | 2023 |
| المجموعة: | Uppsala University: Publications (DiVA) |
| مصطلحات موضوعية: | Prostate cancer, Smoking, Prospective study, Cancer and Oncology, Cancer och onkologi, Urology and Nephrology, Urologi och njurmedicin |
| الوصف: | Background: Prospective and detailed investigations of smoking and prostate cancer (PCa) risk and death are lacking.Objective: To investigate prediagnosis smoking habit (status, intensity, duration, and cessation) as a risk factor, on its own and combined with body mass index (BMI), for PCa incidence and death. Design, setting, and participants: We included 351 448 men with smoking information from five Swedish cohorts. Outcome measurements and statistical analysis: We used Cox regression to calculate hazard ratios (HRs) and confidence intervals (CIs) for PCa incidence (n = 24 731) and death (n = 4322).Results and limitations: Smoking was associated with a lower risk of any PCa (HR 0.89, 95% CI 0.86-0.92), which was most pronounced for low-risk PCa (HR 0.74, 95% CI 0.69- 0.79) and was restricted to PCa cases diagnosed in the prostate-specific antigen (PSA) era. Smoking was associated with a higher risk of PCa death in the full cohort (HR 1.10, 95% CI 1.02-1.18) and in case-only analysis adjusted for clinical characteristics (HR 1.20, 95% CI 1.11-1.31), which was a consistent finding across case groups (p = 0.8 for heterogeneity). Associations by smoking intensity and, to lesser degree, smoking duration and cessation, supported the associations for smoking status. Smoking in combination with obesity (BMI >= 30 kg/m2) further decreased the risk of low-risk PCa incidence (HR 0.40, 95% CI 0.30-0.53 compared to never smokers with BMI <25 kg/m2) and further increased the risk of PCa death (HR 1.49, 95% CI 1.21-1.84). A limitation of the study is that only a subgroup of men had information on smoking habit around the time of their PCa diagnosis.Conclusions: The lower PCa risk for smokers in the PSA era, particularly for low-risk PCa, can probably be attributed to low uptake of PSA testing by smokers. Poor survival for |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | European Urology, 0302-2838, 2023, 83:5, s. 422-431; orcid:0000-0001-6808-4405; orcid:0000-0002-8306-0687; http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-503233Test; PMID 35523620; ISI:000983056500001 |
| DOI: | 10.1016/j.eururo.2022.03.033 |
| الإتاحة: | https://doi.org/10.1016/j.eururo.2022.03.033Test http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-503233Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B32683C9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.eururo.2022.03.033 |
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