دورية أكاديمية

Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against

التفاصيل البيبلوغرافية
العنوان: Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
المؤلفون: Elwood, Peter, Morgan, Gareth, Watkins, John, Protty, Majd, Mason, Malcolm, Adams, Richard, Dolwani, Sunil, Pickering, Janet, Delon, Christine, Longley, Marcus
بيانات النشر: Springer Nature
سنة النشر: 2024
المجموعة: Cardiff University: ORCA (Online Research @ Cardiff)
الوصف: Aspirin as a possible treatment of cancer has been of increasing interest for over 50 years, but the balance of the risks and benefits remains a point of contention. We summarise the valid published evidence ‘for’ and ‘against’ the use of aspirin as a cancer treatment and we present what we believe are relevant ethical implications. Reasons for aspirin include the benefits of aspirin taken by patients with cancer upon relevant biological cancer mechanisms. These explain the observed reductions in metastatic cancer and vascular complications in cancer patients. Meta-analyses of 118 observational studies of mortality in cancer patients give evidence consistent with reductions of about 20% in mortality associated with aspirin use. Reasons against aspirin use include increased risk of a gastrointestinal bleed though there appears to be no valid evidence that aspirin is responsible for fatal gastrointestinal bleeding. Few trials have been reported and there are inconsistencies in the results. In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
العلاقة: https://orca.cardiff.ac.uk/id/eprint/165181/1/s41416-023-02506-5.pdfTest; Elwood, Peter, Morgan, Gareth https://orca.cardiff.ac.uk/view/cardiffauthors/A023484G.htmlTest, Watkins, John https://orca.cardiff.ac.uk/view/cardiffauthors/A037082U.htmlTest, Protty, Majd https://orca.cardiff.ac.uk/view/cardiffauthors/A1427892W.htmlTest, Mason, Malcolm https://orca.cardiff.ac.uk/view/cardiffauthors/A008319Q.htmlTest orcid:0000-0003-1505-2869 orcid:0000-0003-1505-2869, Adams, Richard https://orca.cardiff.ac.uk/view/cardiffauthors/A104870D.htmlTest orcid:0000-0003-3915-7243 orcid:0000-0003-3915-7243, Dolwani, Sunil https://orca.cardiff.ac.uk/view/cardiffauthors/A031553M.htmlTest orcid:0000-0002-3113-5472 orcid:0000-0002-3113-5472, Pickering, Janet https://orca.cardiff.ac.uk/view/cardiffauthors/A415778S.htmlTest, Delon, Christine and Longley, Marcus 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130 , pp. 3-8. 10.1038/s41416-023-02506-5 https://doi.org/10.1038/s41416-023-02506-5Test file https://orca.cardiff.ac.uk/id/eprint/165181/1/s41416-023-02506-5.pdfTest
DOI: 10.1038/s41416-023-02506-5
الإتاحة: https://doi.org/10.1038/s41416-023-02506-5Test
https://orca.cardiff.ac.uk/id/eprint/165181Test/
https://orca.cardiff.ac.uk/id/eprint/165181/1/s41416-023-02506-5.pdfTest
حقوق: cc_by_4_0
رقم الانضمام: edsbas.B2EE1B11
قاعدة البيانات: BASE